Portal de investigação
Sensitization trajectories to multiple allergen components in a population-based birth-cohort
Autores da FMUP
Participantes de fora da FMUP
- Farraia, M
- Mendes, FC
- Severo, M
- Rufo, JC
Unidades de investigação
Abstract
BackgroundThe characteristics of allergic sensitization profiles can differ between populations and geographic regions, contributing differently to the association with allergic diseases. Consequently, the sensitization trajectories found in previous studies conducted in Northern Europe may not apply in Southern European countries. ObjectiveTo identify trajectories of allergic sensitization profiles during childhood and evaluate the association with allergic outcomes, using data from a Portuguese birth cohort. MethodsA random sample from Generation XXI was screened for allergic sensitization at 10 years of age. Among 452 allergic sensitized children, 186 were tested with ImmunoCAP((TM)) ISAC multiplex array that detects 112 molecular components, at three follow-ups (4, 7, and 10 years old). Information on allergic outcomes (asthma, rhinitis, atopic dermatitis) was obtained at the 13-year-old follow-up. Latent class analysis (LCA) was used to identify clusters of participants with similar sensitization profiles. Then, sensitization trajectories were defined based on the most prevalent transitions between clusters over time. Logistic regression was applied to estimate the association between sensitization trajectories and allergic diseases. ResultsFive trajectories were proposed: "no/few sensitizations," "early persistent house dust mites (HDM)," "early HDM and persistent/late grass pollen," "late grass pollen," and "late HDM." The "early HDM and persistent/late grass pollen" trajectory was associated with rhinitis and "early persistent HDM" with asthma and rhinitis. ConclusionDistinct sensitization trajectories pose different risks in the development of allergic diseases. These trajectories present some differences from those in Northern European countries and are important for planning adequate prevention health plans.
Dados da publicação
- ISSN/ISSNe:
- 1399-3038, 0905-6157
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1111/pai.13963
- Link para outro recurso:
- www.scopus.com
Pediatric Allergy and Immunology Blackwell Munksgaard
Citações Recebidas na Scopus: 3
Documentos
- Não há documentos
Filiações
Keywords
- allergen; allergic diseases; asthma; atopic dermatitis; birth-cohort; molecular sensitization; rhinitis; sensitization trajectories
Proyectos asociados
Airborne food and aeroallergens levels in healthcare settings. An unaccounted but potentially relevant source of exposure?
Investigador Principal: André Miguel Afonso de Sousa Moreira
Estudo Clínico Académico (Aeroallergens) . 2020
Eosinophil cationic protein (ECP) correlates with eosinophil cell counts in the induced sputum of elite swimmers
Investigador Principal: André Miguel Afonso de Sousa Moreira
Estudo Clínico Académico (ECP) . 2021
Efetividade do Controlo da Schistosomíase e Comorbilidades no Bengo, Angola.
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Cuidados Prénatais e sua Influência nos Resultados da Gravidez e do Parto, Luanda-Angola.
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Breast milk feeding practices among very preterm infants: effects on health-related outcomes during childhood.
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Data from a Health and Demographic Surveillance System and a Verbal Autopsy System in Dande, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Preexposure prophylaxis for HIV prevention among men who have sex with men: understanding eligibility and early uptake
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2021
Eficácia de intervenções educacionais comunitárias em nutrição e WASH (Water, Sanitation and Hygiene) / Malária na diminuição da prevalência de anemia e malnutrição em crianças menores de 5 anos
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2021
How exercise, physical activity and diet modulate immune and stress responses
Investigador Principal: André Miguel Afonso de Sousa Moreira
Estudo Clínico Académico . 2020
Estudo dos factores de risco cardiovascular numa população adulta da Província do Bengo, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2019
Citar a publicação
Farraia M,Mendes FC,Sokhatska O,Severo M,Rufo JC,Barros H,Moreira A. Sensitization trajectories to multiple allergen components in a population-based birth-cohort. Pediatr. Allergy Immunol. 2023. 34. (6):e13963. IF:4,400. (1).
