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  3. Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis

Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • Bernardo Manuel De Sousa Pinto

    Autor

  • João De Almeida Lopes Da Fonseca

    Autor

Participantes de fora da FMUP

  • Bousquet, J
  • Melén, E
  • Haahtela, T
  • Koppelman, GH
  • Togias, A
  • Valenta, R
  • Akdis, CA
  • Czarlewski, W
  • Rothenberg, M
  • Valiulis, A
  • Wickman, M
  • Akdis, M
  • Aguilar, D
  • Bedbrook, A
  • Bindslev-Jensen, C
  • Bosnic-Anticevich, S
  • Boulet, LP
  • Brightling, CE
  • Brussino, L
  • Burte, E
  • Bustamante, M
  • Canonica, GW
  • Cecchi, L
  • Celedon, JC
  • Loureiro, CC
  • Costa, E
  • Cruz, AA
  • Erhola, M
  • Gemicioglu, B
  • Fokkens, WJ
  • Garcia-Aymerich, J
  • Guerra, S
  • Heinrich, J
  • Ivancevich, JC
  • Keil, T
  • Klimek, L
  • Kuna, P
  • Kupczyk, M
  • Kvedariene, V
  • Larenas-Linnemann, DE
  • Lemonnier, N
  • Carlsen, KCL
  • Louis, R
  • Makela, M
  • Makris, M
  • Maurer, M
  • Momas, I
  • Morais-Almeida, M
  • Mullol, J
  • Naclerio, RN
  • Nadeau, K
  • Nadif, R
  • Niedoszytko, M
  • Okamoto, Y
  • Ollert, M
  • Papadopoulos, NG
  • Passalacqua, G
  • Patella, V
  • Pawankar, R
  • Pham-Thi, N
  • Pfaar, O
  • Regateiro, FS
  • Ring, J
  • Rouadi, PW
  • Samolinski, B
  • Sastre, J
  • Savouré, M
  • Scichilone, N
  • Shamji, MH
  • Sheikh, A
  • Siroux, V
  • Standl, M
  • Sunyer, J
  • Taborda-Barata, L
  • Toppila-Salmi, S
  • Torres, MJ
  • Tsiligianni, I
  • Valovirta, E
  • Vandenplas, O
  • Ventura, MT
  • Weiss, S
  • Yorgancioglu, A
  • Zhang, L
  • Latiff, AHA
  • Aberer, W
  • Agache, I
  • Al-Ahmad, M
  • Alobid, I
  • Ansotegui, IJ
  • Arshad, SH
  • Asayag, E
  • Barbara, C
  • Baharudin, A
  • Battur, L
  • Bennoor, KS
  • Berghea, EC
  • Bergmann, KC
  • Bernstein, D
  • Bewick, M
  • Blain, H
  • Bonini, M
  • Braido, F
  • Buhl, R
  • Bumbacea, RS
  • Bush, A
  • Calderon, M
  • Calvo-Gil, M
  • Camargos, P
  • Caraballo, L
  • Cardona, V
  • Carr, W
  • Carreiro-Martins, P
  • Casale, T
  • Sarabia, AMC
  • Chandrasekharan, R
  • Charpin, D
  • Chen, YZ
  • Cherrez-Ojeda, I
  • Chivato, T
  • Chkhartishvili, E
  • Christoff, G
  • Chu, DK
  • Cingi, C
  • de Sousa, JC
  • Corrigan, C
  • Custovic, A
  • D'Amato, G
  • Del Giacco, S
  • De Blay, F
  • Devillier, P
  • Didier, A
  • Teixeira, MD
  • Dokic, D
  • Douagui, H
  • Doulaptsi, M
  • Durham, S
  • Dykewicz, M
  • Eiwegger, T
  • El-Sayed, ZA
  • Emuzyte, R
  • Fiocchi, A
  • Fyhrquist, N
  • Gomez, RM
  • Gotua, M
  • Guzman, MA
  • Hagemann, J
  • Hamamah, S
  • Halken, S
  • Halpin, DMG
  • Hofmann, M
  • Hossny, E
  • Hrubisko, M
  • Irani, C
  • Ispayeva, Z
  • Jares, E
  • Jartti, T
  • Jassem, E
  • Julge, K
  • Just, J
  • Jutel, M
  • Kaidashev, I
  • Kalayci, O
  • Kalyoncu, AF
  • Kardas, P
  • Kirenga, B
  • Kraxner, H
  • Kull, I
  • Kulus, M
  • La Grutta, S
  • Lau, S
  • Thi, LL
  • Levin, M
  • Lipworth, B
  • Lourenço, O
  • Mahboub, B
  • Martinez-Infante, E
  • Matricardi, P
  • Miculinic, N
  • Migueres, N
  • Mihaltan, F
  • Mohammad, Y
  • Moniuszko, M
  • Montefort, S
  • Neffen, H
  • Nekam, K
  • Nunes, E
  • Tshipukane, DN
  • O'Hehir, R
  • Ogulur, I
  • Ohta, K
  • Okubo, K
  • Ouedraogo, S
  • Olze, H
  • Pali-Schöll,
  • Palomares, O
  • Palosuo, K
  • Panaitescu, C
  • Panzner, P
  • Park, HS
  • Pitsios, C
  • Plavec, D
  • Popov, TA
  • Puggioni, F
  • Quirce, S
  • Recto, M
  • Repka-Ramirez, MS
  • Cordeiro, CR
  • Roche, N
  • Rodriguez-Gonzalez, M
  • Romantowski, J
  • Rosario, N
  • Rottem, M
  • Sagara, H
  • Serpa, FS
  • Sayah, Z
  • Scheire, S
  • Schmid-Grendelmeier, P
  • Sisul, JC
  • Sole, D
  • Soto-Martinez, M
  • Sova, M
  • Sperl, A
  • Spranger, O
  • Stelmach, R
  • Ulrik, CS
  • Thomas, M
  • To, T
  • Todo-Bom, A
  • Tomazic, PV
  • Urrutia-Pereira, M
  • Valentin-Rostan, M
  • Van Ganse, E
  • van Hage, M
  • Vasankari, T
  • Vichyanond, P
  • Viegi, G
  • Wallace, D
  • Wang, DY
  • Williams, S
  • Worm, M
  • Yiallouros, P
  • Yusuf, O
  • Zaitoun, F
  • Zernotti, M
  • Zidarn, M
  • Zuberbier, J
  • Zuberbier, T
  • Anto, JM

Unidades de investigação

Abstract

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.

© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Dados da publicação

ISSN/ISSNe:
0105-4538, 1398-9995

ALLERGY  Wiley-Blackwell Publishing Ltd

Tipo:
Review
Páginas:
1169-1203
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 5

Citações Recebidas na Scopus: 43

Documentos

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Métricas

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Keywords

  • asthma; IL-33; multimorbidity; rhinitis; Toll-like receptors

Campos de estudo

Proyectos asociados

Prevalence and Characterisation of Asthma Patients According to Disease Severity in Portugal (EPI-ASTHMA) - NCT05169619

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Observacional (EPI-ASTHMA) . AstraZeneca . 2021

Effect of a Mobile App on Improving Asthma Control in Adolescents and Adults With Persistent Asthma: A Pilot Randomized Multicentre, Superiority Clinical Trial (mINSPIRERS) - NCT05129527

Investigador Principal: João de Almeida Lopes da Fonseca

Ensaio Clínico Académico (mINSPIRERS) . 2021

Utilização em estudos observacionais do Registo de Asma Grave Portugal.

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Observacional Académico (RAG) . 2020

Clinical Research Collaboration Severe Heterogenous Asthma Research collaboration, Patient-centered (CRC SHARP).

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Observacional (SHARP) . European Respiratory Society . 2021

Multidimensional phenotyping of severe asthma patients and its impact on disease control and therapeutic response - analysis from the Portuguese Severe Asthma Registry.

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Observacional (RAG-SPP-GSK) . SPPneumologia . 2022

BREATHE - An oBservational, pRimary data study to characterize severe AsThma pHenotypes and assEss disease burden across the EUCAN region.

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Observacional (RAG-AZ-BREATHE) . AstraZeneca . 2022

Seroprevalence of SARS-CoV-2 and assessment of epidemiologic determinants in Portuguese municipal workers

Investigador Principal: Bernardo Manuel De Sousa Pinto

Estudo Clínico Académico (SARS-CoV-2) . 2021

Efficiency in Spine Care ? Assessing outcomes and costs to inform healthcare improvement

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Académico . 2022

Use of secondary data, health technology assessment methods and economic modelling applied to penicillin allergy

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Académico . 2020

Using different data sources for the identification of asthma patients and those at high risk of adverse outcomes

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Académico . 2020

Phenotypes of Chronic Diseases of the Airways: Towards Multidimensional Data -Driven Profiling

Investigador Principal: João de Almeida Lopes da Fonseca

Estudo Clínico Académico . 2020

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