Portal de investigação
Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Collatuzzo, G
- Negri, E
- Pelucchi, C
- Bonzi, R
- Turati, F
- Rabkin, CS
- Liao, LM
- Sinha, R
- Palli, D
- Ferraroni, M
- López-Carrillo, L
- Morais, S
- Albanes, D
- Weinstein, SJ
- Parisi, D
- Zaridze, D
- Maximovitch, D
- Dierssen-Sotos, T
- Jiménez-Moleón, JJ
- Vioque, J
- de la Hera, MG
- Curado, MP
- Dias-Neto, E
- Hernández-Ramírez, RU
- López-Cervantes, M
- Ward, MH
- Tsugane, S
- Hidaka, A
- Lagiou, A
- Lagiou, P
- Zhang, ZF
- Trichopoulou, A
- Karakatsani, A
- Camargo, MC
- La Vecchia, C
- Boffetta, P
Unidades de investigação
Abstract
Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
Dados da publicação
- ISSN/ISSNe:
- 2072-6643, 2072-6643
- Tipo:
- Article
- Páginas:
- 1877-
- DOI:
- 10.3390/nu15081877
- PubMed:
- 37111097
- Link para outro recurso:
- www.scopus.com
Nutrients Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Scopus: 4
Documentos
- Não há documentos
Filiações
Keywords
- gastric cancer; diet; nutrition; yoghurt
Financiamento
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