Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

Data de publicação:

Autores da FMUP

  • Nuno Miguel De Sousa Lunet

    Autor

Participantes de fora da FMUP

  • Collatuzzo, G
  • Negri, E
  • Pelucchi, C
  • Bonzi, R
  • Turati, F
  • Rabkin, CS
  • Liao, LM
  • Sinha, R
  • Palli, D
  • Ferraroni, M
  • López-Carrillo, L
  • Morais, S
  • Albanes, D
  • Weinstein, SJ
  • Parisi, D
  • Zaridze, D
  • Maximovitch, D
  • Dierssen-Sotos, T
  • Jiménez-Moleón, JJ
  • Vioque, J
  • de la Hera, MG
  • Curado, MP
  • Dias-Neto, E
  • Hernández-Ramírez, RU
  • López-Cervantes, M
  • Ward, MH
  • Tsugane, S
  • Hidaka, A
  • Lagiou, A
  • Lagiou, P
  • Zhang, ZF
  • Trichopoulou, A
  • Karakatsani, A
  • Camargo, MC
  • La Vecchia, C
  • Boffetta, P

Unidades de investigação

Abstract

Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.

Dados da publicação

ISSN/ISSNe:
2072-6643, 2072-6643

Nutrients  Multidisciplinary Digital Publishing Institute (MDPI)

Tipo:
Article
Páginas:
1877-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 4

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Keywords

  • gastric cancer; diet; nutrition; yoghurt

Financiamento

Proyectos asociados

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Estudo Clínico Académico (Cognitive Decline) . 2022

Healthcare use among cancer patients and their partners in different phases of the cancer pathway

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Estudo Clínico Académico . 2021

Reshaping organized cervical cancer screening: strategies to increase the adherence and reduce invitation costs

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Estudo Clínico Académico . 2020

Using pooled analyses based on individual participant data for a finer assessment of gastric cancer etiology

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Estudo Clínico Académico . 2020

RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK

Investigador Principal: Nuno Miguel de Sousa Lunet

Estudo Clínico Académico . 2019

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