Portal de investigação
Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Regateiro, FS
- Czarlewski, W
- Kulus, M
- Shamji, MH
- Boulet, LP
- Bonini, M
- Brussino, L
- Canonica, GW
- Cruz, AA
- Gemicioglu, B
- Haahtela, T
- Kupczyk, M
- Kvedariene, V
- Larenas-Linnemann, D
- Louis, R
- Niedoszytko, M
- Nhan, PT
- Puggioni, F
- Romantowski, J
- Sastre, J
- Scichilone, N
- Taborda Barata, L
- Ventura, MT
- Agache, I
- Bedbrook, A
- Bergmann, KC
- Bosnic Anticevich, S
- Brusselle, G
- Buhl, R
- Cecchi, L
- Charpin, D
- Loureiro, CC
- de Blay, F
- Del Giacco, S
- Devillier, P
- Jassem, E
- Joos, G
- Jutel, M
- Klimek, L
- Kuna, P
- Laune, D
- Pech, JL
- Makela, M
- Morais-Almeida, M
- Nadif, R
- Neffen, HE
- Ohta, K
- Papadopoulos, NG
- Papi, A
- Pétré, B
- Pfaar, O
- Yeverino, DR
- Cordeiro, CR
- Roche, N
- Samolinski, B
- Sheikh, A
- Ulrik, CS
- Usmani, OS
- Valiulis, A
- Vandenplas, O
- Yorgancioglu, A
- Zuberbier, T
- Anto, JM
- Bousquet, J
Unidades de investigação
Abstract
Background Validated questionnaires are used to assess asthma control over the past 1-4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16-90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test-retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0.68-0.82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0.59-0.68). They also displayed high test-retest reliability (intraclass correlation coefficients range 0.79-0.95) and moderate-to-high responsiveness (correlation coefficient range 0.69-0.79; effect size measures range 0.57-0.99 in the comparison with VAS dyspnoea). The best-performing score displayed a strong correlation with the effect of asthma on work and school activities in the INSPIRERS cohort (Spearman correlation coefficients 0.70; 95% CI 0.61-0.78) and good accuracy for the identification of patients with uncontrolled or partly controlled asthma according to GINA (area under the receiver operating curve 0.73; 95% CI 0.68-0.78). Interpretation e-DASTHMA is a good tool for the daily assessment of asthma control. This tool can be used as an endpoint in clinical trials as well as in clinical practice to assess fluctuations in asthma control and guide treatment optimisation. Funding None. Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.
Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 2589-7500, 2589-7500
- Tipo:
- Article
- Páginas:
- 227-238
- Link para outro recurso:
- www.scopus.com
LANCET DIGITAL HEALTH Elsevier Ltd.
Citações Recebidas na Web of Science: 2
Citações Recebidas na Scopus: 19
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Filiações
Keywords
- RESPONSIVENESS; QUESTIONNAIRE; RELIABILITY; INSTRUMENTS; RHINITIS
Financiamento
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Citar a publicação
Sousa B,Jacome C,Pereira A,Regateiro FS,Almeida R,Czarlewski W,Kulus M,Shamji MH,Boulet LP,Bonini M,Brussino L,Canonica GW,Cruz AA,Gemicioglu B,Haahtela T,Kupczyk M,Kvedariene V,Larenas D,Louis R,Niedoszytko M,Nhan PT,Puggioni F,Romantowski J,Sastre J,Scichilone N,Taborda L,Ventura MT,Vieira R,Agache I,Bedbrook A,Bergmann KC,Amaral R,Azevedo L,Bosnic S,Brusselle G,Buhl R,Cecchi L,Charpin D,Loureiro CC,de Blay F,Del Giacco S,Devillier P,Jassem E,Joos G,Jutel M,Klimek L,Kuna P,Laune D,Pech JL,Makela M,Morais M,Nadif R,Neffen HE,Ohta K,Papadopoulos NG,Papi A,Pétré B,Pfaar O,Yeverino DR,Cordeiro CR,Roche N,Samolinski B,Samolinski B,Sheikh A,Ulrik CS,Usmani OS,Valiulis A,Vandenplas O,Vieira P,Yorgancioglu A,Zuberbier T,Anto JM,Fonseca JA,Bousquet J. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study. Lancet Digit. Health. 2023. 5. (4):p. 227-238. IF:30,800. (1).
