1. Início
  2. Publicações
  3. Investigation of the clinical utility of adhesion molecules in the management of thyroid nodules

Investigation of the clinical utility of adhesion molecules in the management of thyroid nodules

Data de publicação:

Autores da FMUP

  • Valdemar De Jesus Conde Máximo

    Autor

Participantes de fora da FMUP

  • Rabi, LT
  • Peres, KC
  • Nascimento, M
  • Teixeira, ED
  • de Freitas, LLL
  • Barreto, IS
  • Geraldo, MV
  • Assumpçao, LVM
  • Tincani, AJ
  • Bufalo, NE
  • Ward, LS

Unidades de investigação

Abstract

To better understand the relationship among cell adhesion molecules (CAM) and investigate the clinical diagnostic and prognostic application of ICAM-1 (ICAM1), LFA-1 (ITGAL), and L-selectin (SELL) proteins and mRNA corresponding expression in thyroid cancer. Gene expression was evaluated by RT-qPCR, and protein expression was evaluated by immunohistochemistry. We evaluated 275 patients (218 women, 57 men, 48.4 +/- 14.5 years old), including 102 benign and 173 malignant nodules. The 143 papillary thyroid carcinoma (PTC) and 30 follicular thyroid carcinoma (FTC) patients were managed according to current guidelines and followed-up for 78.7 +/- 54.2 months. Malignant and benign nodules differed concerning mRNA (p = 0.0027) and protein (p = 0.0020 for nuclear) expression of L-selectin and ICAM-1 (mRNA: p = 0.0001 and protein: p = 0.0014) and protein expression of LFA-1 (p = 0.0168), but not mRNA expression of LFA-1 (p = 0.2131). SELL expression was more intense in malignant tumors (p = 0.0027). ICAM1 (p = 0.0064) and ITGAL (p = 0.0244) mRNA expression was higher in tumors with lymphocyte infiltrate. ICAM-1 expression correlated with younger age at diagnosis (p = 0.0312) and smaller tumor size (p = 0.0443). Also, LFA-1 expression correlated with higher age at diagnosis (p = 0.0376) and was more intense at stage III and IV (p = 0.0077). In general, the protein expression of the 3 CAM decreased as the process of cellular dedifferentiation occurred. We suggest that the SELL and ICAM1 genes and L-selectin and LFA-1 protein expression may help confirm malignancy and assist in the histological characterization of follicular patterned lesions, but we were unable to correlate these CAMs with patient outcomes.

Dados da publicação

ISSN/ISSNe:
2045-2322, 2045-2322

Scientific Reports  Nature Publishing Group

Tipo:
Article
Páginas:
-
PubMed:
36906717
Link para outro recurso:
www.scopus.com

Citações Recebidas na Scopus: 2

Documentos

  • Não há documentos

Métricas

Filiações mostrar / ocultar

Keywords

  • INTEGRIN-MEDIATED ADHESION; LYMPHOCYTIC THYROIDITIS; UP-REGULATION; CANCER; ICAM-1; INFLAMMATION; GROWTH; CELLS; METASTASIS; EXPRESSION

Campos de Estudo

Projetos associados

Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla

Investigador Principal: Valdemar de Jesus Conde Máximo

Estudo Clínico Académico (Mitochondrial) . 2020

Role of the MITOchondrial fission protein DRP1 as a prognosis and predictive biomarker in the treatment of differentiated thyroid cancer (ROMITO-DRP1)

Investigador Principal: Valdemar de Jesus Conde Máximo

Estudo Clínico Académico . 2022

New Biomarkers development, validation and application in Bladder Cancer.

Investigador Principal: Valdemar de Jesus Conde Máximo

Estudo Clínico Académico . 2021

Partilhar a publicação