Portal de investigação
Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Elhakeem, A
- Taylor, AE
- Inskip, HM
- Huang, JY
- Mansell, T
- Rodrigues, C
- Asta, F
- Blaauwendraad, SM
- Haberg, SE
- Halliday, J
- Harskamp-van Ginkel, MW
- He, JR
- Jaddoe, VWV
- Lewis, S
- Maher, GM
- Manios, Y
- McCarthy, FP
- Reiss, IKM
- Rusconi, F
- Salika, T
- Tafflet, M
- Qiu, X
- Asvold, BO
- Burgner, D
- Chan, JKY
- Gagliardi, L
- Gaillard, R
- Heude, B
- Magnus, MC
- Moschonis, G
- Murray, D
- Nelson, SM
- Porta, D
- Saffery, R
- Eriksson, JG
- Vrijkotte, TGM
- Lawlor, DA
Unidades de investigação
Abstract
Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (-0.53 mmHg; 95% CI:-1.59 to 0.53), DBP (-0.24 mmHg; -0.83 to 0.35), or HR (0.02 beat/min; -0.91 to 0.94). Total cholesterol (2.59%; 0.10-5.07), HDL cholesterol (4.16%; 2.52-5.81), LDL cholesterol (4.95%; 0.47-9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant. Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
Dados da publicação
- ISSN/ISSNe:
- 1522-9645, 0195-668X
- Tipo:
- Article
- Páginas:
- 1464-1464
European Heart Journal Oxford University Press
Citações Recebidas na Web of Science: 3
Documentos
- Não há documentos
Filiações
Keywords
- Blood pressure; Glucose; In vitro fertilization; Lipids; Meta-analysis; Pooled longitudinal trajectory analysis
Financiamento
Proyectos asociados
Efetividade do Controlo da Schistosomíase e Comorbilidades no Bengo, Angola.
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Cuidados Prénatais e sua Influência nos Resultados da Gravidez e do Parto, Luanda-Angola.
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Breast milk feeding practices among very preterm infants: effects on health-related outcomes during childhood.
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Data from a Health and Demographic Surveillance System and a Verbal Autopsy System in Dande, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2022
Preexposure prophylaxis for HIV prevention among men who have sex with men: understanding eligibility and early uptake
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2021
Eficácia de intervenções educacionais comunitárias em nutrição e WASH (Water, Sanitation and Hygiene) / Malária na diminuição da prevalência de anemia e malnutrição em crianças menores de 5 anos
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2021
Estudo dos factores de risco cardiovascular numa população adulta da Província do Bengo, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2019
Citar a publicação
Elhakeem A,Taylor AE,Inskip HM,Huang JY,Mansell T,Rodrigues C,Asta F,Blaauwendraad SM,Haberg SE,Halliday J,Harskamp MW,He JR,Jaddoe VWV,Lewis S,Maher GM,Manios Y,McCarthy FP,Reiss I,Rusconi F,Salika T,Tafflet M,Qiu X,Asvold BO,Burgner D,Chan JKY,Gagliardi L,Gaillard R,Heude B,Magnus MC,Moschonis G,Murray D,Nelson SM,Porta D,Saffery R,Barros H,Eriksson JG,Vrijkotte TGM,Lawlor DA. Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis. Eur. Heart J. 2023. 44. (16):p. 1464-1464. IF:39,300. (1).
