Portal de investigação
Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Elhakeem, A
- Taylor, AE
- Inskip, HM
- Huang, JY
- Mansell, T
- Rodrigues, C
- Asta, F
- Blaauwendraad, SM
- Haberg, SE
- Halliday, J
- Harskamp-van Ginkel, MW
- He, JR
- Jaddoe, VWV
- Lewis, S
- Maher, GM
- Manios, Y
- McCarthy, FP
- Reiss, IKM
- Rusconi, F
- Salika, T
- Tafflet, M
- Qiu, X
- Asvold, BO
- Burgner, D
- Chan, JKY
- Gagliardi, L
- Gaillard, R
- Heude, B
- Magnus, MC
- Moschonis, G
- Murray, D
- Nelson, SM
- Porta, D
- Saffery, R
- Eriksson, JG
- Vrijkotte, TGM
- Lawlor, DA
Unidades de investigação
Abstract
Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (-0.53 mmHg; 95% CI:-1.59 to 0.53), DBP (-0.24 mmHg; -0.83 to 0.35), or HR (0.02 beat/min; -0.91 to 0.94). Total cholesterol (2.59%; 0.10-5.07), HDL cholesterol (4.16%; 2.52-5.81), LDL cholesterol (4.95%; 0.47-9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant. Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
Dados da publicação
- ISSN/ISSNe:
- 1522-9645, 0195-668X
- Tipo:
- Article
- Páginas:
- 1464-1464
- PubMed:
- 36740401
European Heart Journal Oxford University Press
Citações Recebidas na Web of Science: 3
Documentos
- Não há documentos
Filiações
Keywords
- Blood pressure; Glucose; In vitro fertilization; Lipids; Meta-analysis; Pooled longitudinal trajectory analysis
Financiamento
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