Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis

Autores da FMUP
Participantes de fora da FMUP
- Costa, T
- Nogueiro, J
- Ribeiro, D
- Viegas, P
Unidades de investigação
Abstract
Introduction/aimSerum albumin concentration (COA) and neutrophil-lymphocyte ratio (NLR) could reflect immunological and nutritional status. We aim to evaluate the impact of COA-NLR score on the prognosis of gastric cancer (GC).Material and methodsWe perform a retrospective analysis on a database of 637 GC cases, between January 2010 and December 2017. In 396 patients, the inclusion criteria for this study were met (non-resectional or palliative surgery were excluded). Analytic data was only available in 203 patients. COA-NLR score was defined as follows: COA under 35 g/L and NLR value of 2.585 or higher, score 2; one of these conditions, score 1; and neither, score 0.ResultsIn our population (n = 203), 87 patients were classified as score 0, 82 as score 1 and 34 as score 2. COA-NLR score was significantly associated with DFS (HR 1.674; CI 95% 1.115-2.513; p = 0.013) and with OS (HR 2.072; CI 95% 1.531-2.805; p < 0.001). Kaplan-Meier curve analysis (log rank test) revealed that a higher score of COA-NLR predicted a worse OS (p < 0.001) and DFS (p = 0.03). COA-NLR was an independent prognostic factor for OS when adjusted to pStage and age (adjusted HR 1.566; CI 95% 1.145-2.143; p = 0.005).ConclusionsPreoperative COA-NLR score was significantly associated with worse OS and DFS and, in this way, with worse prognosis on GC patients submitted to curative-intent resectional surgery.
Dados da publicação
- ISSN/ISSNe:
- 1435-2451, 1435-2443
- Tipo:
- Article
- Páginas:
- -
LANGENBECKS ARCHIVES OF SURGERY Springer Verlag
Citações Recebidas na Web of Science: 2
Documentos
- Não há documentos
Filiações
Keywords
- Serum albumin concentration; Neutrophil-to-lymphocyte ratio; Gastric cancer prognosis; Curative-intent resectional surgery
Proyectos asociados
Impact of Platelet-Lymphocyte Ratio (PLR) in the prognosis of Gastric Cancer patients
Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa
Estudo Clínico Académico (PLR) . 2020
Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis
Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa
Estudo Clínico Académico (gastric cancer prognosis . 2020
Nutritional deficiencies in bariatric surgery patients: a comparison between Roux-en-Y Gastric Bypass and Sleeve Gastrectomy
Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa
Estudo Clínico Académico . 2021
Roux-en-Y Gastric Bypass and Sleeve Gastrectomy as Revisional Bariatric Procedures after Adjustable Gastric Banding: a retrospective cohort study
Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa
Estudo Clínico Académico (Gastric Bypass) . 2021
High-Sensitivity modified Glasgow Prognostic Score (HS-mGPS) as a predictor of overall survival in gastric cancer patients submitted to curative-intent surgery
Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa
Estudo Clínico Académico . 2020
Citar a publicação
Costa T,Nogueiro J,Ribeiro D,Viegas P,Santos H. Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis. Langenbeck's Arch. Surg. 2023. 408. (1):57. IF:2,300. (2).