Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis

Data de publicação:

Autores da FMUP

  • Hugo Miguel Teixeira Ferraz Santos Sousa

    Autor

Participantes de fora da FMUP

  • Costa, T
  • Nogueiro, J
  • Ribeiro, D
  • Viegas, P

Unidades de investigação

Abstract

Introduction/aimSerum albumin concentration (COA) and neutrophil-lymphocyte ratio (NLR) could reflect immunological and nutritional status. We aim to evaluate the impact of COA-NLR score on the prognosis of gastric cancer (GC).Material and methodsWe perform a retrospective analysis on a database of 637 GC cases, between January 2010 and December 2017. In 396 patients, the inclusion criteria for this study were met (non-resectional or palliative surgery were excluded). Analytic data was only available in 203 patients. COA-NLR score was defined as follows: COA under 35 g/L and NLR value of 2.585 or higher, score 2; one of these conditions, score 1; and neither, score 0.ResultsIn our population (n = 203), 87 patients were classified as score 0, 82 as score 1 and 34 as score 2. COA-NLR score was significantly associated with DFS (HR 1.674; CI 95% 1.115-2.513; p = 0.013) and with OS (HR 2.072; CI 95% 1.531-2.805; p < 0.001). Kaplan-Meier curve analysis (log rank test) revealed that a higher score of COA-NLR predicted a worse OS (p < 0.001) and DFS (p = 0.03). COA-NLR was an independent prognostic factor for OS when adjusted to pStage and age (adjusted HR 1.566; CI 95% 1.145-2.143; p = 0.005).ConclusionsPreoperative COA-NLR score was significantly associated with worse OS and DFS and, in this way, with worse prognosis on GC patients submitted to curative-intent resectional surgery.

Dados da publicação

ISSN/ISSNe:
1435-2451, 1435-2443

LANGENBECKS ARCHIVES OF SURGERY  Springer Verlag

Tipo:
Article
Páginas:
-

Citações Recebidas na Web of Science: 2

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Keywords

  • Serum albumin concentration; Neutrophil-to-lymphocyte ratio; Gastric cancer prognosis; Curative-intent resectional surgery

Proyectos asociados

Impact of Platelet-Lymphocyte Ratio (PLR) in the prognosis of Gastric Cancer patients

Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa

Estudo Clínico Académico (PLR) . 2020

Impact of serum albumin concentration and neutrophil-lymphocyte ratio score on gastric cancer prognosis

Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa

Estudo Clínico Académico (gastric cancer prognosis . 2020

Nutritional deficiencies in bariatric surgery patients: a comparison between Roux-en-Y Gastric Bypass and Sleeve Gastrectomy

Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa

Estudo Clínico Académico . 2021

Roux-en-Y Gastric Bypass and Sleeve Gastrectomy as Revisional Bariatric Procedures after Adjustable Gastric Banding: a retrospective cohort study

Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa

Estudo Clínico Académico (Gastric Bypass) . 2021

High-Sensitivity modified Glasgow Prognostic Score (HS-mGPS) as a predictor of overall survival in gastric cancer patients submitted to curative-intent surgery

Investigador Principal: Hugo Miguel Teixeira Ferraz Santos Sousa

Estudo Clínico Académico . 2020

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