A RADIOTERAPIA E QUIMIOTERAPIA NEOADJUVANTES PARA PACIENTES COM CANCER DE ESOFAGO E JUNCAO GASTRO-ESOFAGICA AFETAM OS RESULTADOS POS-OPERATORIOS? UM ESTUDO USANDO O SISTEMA DE REGRESSAO TUMORAL DE BECKER E REGRESSAO DE LINFONODOS.

Autores da FMUP

• Irene Gullo

  Autor

• José Adelino Lobarinhas Barbosa

  Autor

Participantes de fora da FMUP

• do Rosario, MIV
• Barbosa, JP

Unidades de investigação

• Cirurgia e Fisiologia

• Patologia

Abstract

BACKGROUND: The effect of neoadjuvant chemoradiotherapy (nCRT) in patients with locally esquistossomotica com sangramento de varizes e a desconexao azigo-portal mais advanced esophageal cancer can be determined by assessing the Becker tumor regression grade in the primary tumor, as well as in lymph nodes. AIMS: The aim of this study was to investigate the esplenectomia (DAPE) associada a terapia endoscopica. Porem, estudos mostram aumento anatomopathological changes caused by neoadjuvant chemoradiotherapy and their impact on clinical do calibre das varizes em alguns pacientes durante o seguimento em longo prazo.Objetivo: parameters. Specifically, we analyzed the Becker tumor regression grade, lymph node status, and regression Avaliar o impacto da DAPE e tratamento endoscopico pos-operatorio no comportamento changes and evaluated their association with the Clavien-Dindo classification of surgical complications and das varizes esofagicas e recidiva emorragica, de pacientes esquistossomoticos. Metodos: overall patient survival. METHODS: This is a retrospective and observational study including 139 patients Foram estudados 36 pacientes com seguimento superior a cinco anos, distribuidos em diagnosed with adenocarcinoma or squamous cell carcinoma of the esophagus and treated with either neoadjuvant chemoradiotherapy followed by surgery or surgery alone. For the 94 patients who underwent dois grupos: queda da pressao portal abaixo de 30% e acima de 30% comparados com o neoadjuvant chemoradiotherapy, we evaluated tumor regression by Becker tumor regression grade in calibre das varizes esofagicas no pos-operatorio precoce e tardio alem do indice de recidiva primary tumors. We also analyzed lymph node status and regression changes on lymph nodes with or hemrragic. Rsultados without metastases. Overall survival analysis was performed using Kaplan-Meier curves. RESULTS: Becker esofagicas que, durante o seguimento aumentaram de calibre e foram controladas com tumor regression grade is associated with lower lymphatic permeation (p<0.01) and vascular invasion (p<0.001), but not with lymph node regression rate (p=0.10). Clavien-Dindo classification was associated neither with lymph node regression rate (odds ratio=0.784, p=0.795) nor with tumor regression grade o comportamento do calibre das varizes no pos-operatorio precoce nem tardio nem os (p=0.68). Patients who presented with lymphatic permeation and vascular invasion had statistically indices de recidiva hemorragica.Conclusao significantly lower median survival (17 vs. 30 months, p=0.006 for lymphatic permeation, and 14 vs. 29 months, p=0.024 for vascular invasion). CONCLUSION: In our series, we were unable to demonstrate an operatorios precoces ou tardios. A comparacao entre a queda de pressao do portal e as association between Becker tumor regression grade and lymph node regression rate with any postoperative complications. Patients with lower lymphatic permeation and vascular invasion have higher overall survival, correlating with a better response in the Becker tumor regression grade system.

Keywords

• Esophageal neoplasms; Drug therapy; Radiotherapy; Limph node; Postoperative gastricas; complications; Survival