Follicular Growth Pattern Disease on Thyroid Fine-needle Aspiration Biopsy.

Autores da FMUP

• 

  Fernando Carlos De Landér Schmitt

  Autor

Participantes de fora da FMUP

• Tastekin E
• Canberk S

Unidades de investigação

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• Patologia

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Thyroid nodules are a common worldwide health problem and a diagnostic challenge for clinicians and cytopathologists. Follicular growth pattern constitutes the majority of thyroid lesions. Thyroid nodules can be neoplastic or non-neoplastic, and neoplastic nodules can be classified as benign, malignant, or gray zone. Gray zone lesions include different benign and malignant entities that might be resulted in unnecessary thyroidectomies with risk of morbidity and higher health care costs. Depending on the cellularity, most cases might fall into the follicular neoplasia (FN)/ suspicious for FN (SFN) category or follicular lesion of undetermined significance (FLUS) in The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Pathologists must be aware of the relationship between this diagnostic category and follow-up patient management and avoid over-diagnosing by mastering the diagnostic criteria.

Keywords

• Biopsy, Fine-Needle; Humans; Thyroid Neoplasms; Thyroid Nodule; Thyroidectomy; iodine 131; cancer prognosis; cytopathology; diagnostic accuracy; diagnostic error; differential diagnosis; dyshormonogenetic goiter; false negative result; false positive result; fine needle aspiration biopsy; follicular growth pattern disease; follicular neoplasia; follow up; gene expression profiling; gene mutation; histopathology; human; immunocytochemistry; intrathyroidal parathyroid adenoma; microscopy; noninvasive follicular thyroid neoplasm with papillary-like nuclear features; overdiagnosis; papillary and follicular thyroid carcinoma; parathyroid adenoma; poorly differentiated thyroid cancer; predictive value; Review; sensitivity and specificity; suspicious for follicular neoplasia; thyroid cancer; thyroid disease; thyroid follicular adenoma; thyroid follicular carcinoma; thyroid medullary carcinoma; thyroid nodule; tumor volume; fine needle aspiration biopsy; pathology; thyroid nodule; thyroid tumo