Portal de investigação
Risk Factors for Breast Cancer, Overall and by Tumor Subtype, among Women from Mozambique, Sub-Saharan Africa.
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Brandão M
- Guisseve A
- Damasceno A
- Bata G
- Silva-Matos C
- Alberto M
- Ferro J
- Garcia C
- Zaqueu C
- Lorenzoni C
- Leitão D
- Soares O
- Gudo-Morais A
- Morais S
- Tulsidás S
- Carrilho C
Unidades de investigação
Abstract
BACKGROUND: Breast cancer incidence is rising in Africa, but there are scare data regarding risk factors in this region. We assessed the relation between risk factors and the occurrence of breast cancer, overall and by tumor subtype in women from Mozambique. METHODS: The associations between education, number of births, height, weight, body mass index (BMI), and breast cancer risk among 138 cases (participants from the Moza-BC cohort) and 638 controls from the general population (from a World Health Organization stepwise approach to surveillance survey), recruited during 2014 to 2017, were investigated. Adjusted ORs (aOR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression. RESULTS: Multiparity (=6 vs. 0-1 live births) was a protective factor for the development of hormone receptor (HR)-positive (aOR = 0.22; 95% CI, 0.08-0.64) and HR-positive/HER2-negative tumors (aOR = 0.20; 95% CI, 0.06-0.68), whereas a higher educational level (=8 vs. 0 schooling years) increased breast cancer risk across all subtypes (overall aOR = 1.98; 95% CI, 1.04-3.80). Higher weight and BMI were associated with a higher breast cancer risk among postmenopausal women (per 1-kg increase: aOR = 1.05; 95% CI, 1.02-1.08; per 1-kg/m(2) increase: aOR = 1.11; 95% CI, 1.04-1.18, respectively), but were protective in premenopausal women (aOR = 0.98; 95% CI, 0.96-0.99; aOR = 0.95; 95% CI, 0.91-0.99, respectively), regardless of subtype. Higher height increased the risk of HR-negative tumors in postmenopause (per 10-cm increase: aOR = 2.81; 95% CI, 1.41-6.03). CONCLUSION: These results demonstrate the etiological heterogeneity of breast cancer among native African women, namely regarding the differential effect of multiparity, education, and body parameters in breast cancer risk. IMPACT: As the prevalence of obesity grows, these findings are important to inform public health policies on cancer prevention, by highlighting obesity as a modifiable risk factor for breast cancer among African women.
©2021 American Association for Cancer Research.
Dados da publicação
- ISSN/ISSNe:
- 1055-9965, 1538-7755
- Tipo:
- Article
- Páginas:
- 1250-1259
- Link para outro recurso:
- www.scopus.com
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION American Association for Cancer Research Inc.
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 5
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Filiações
Keywords
- Adult; Aged; Aged, 80 and over; Biopsy, Fine-Needle; Body Mass Index; Breast; Breast Neoplasms; Case-Control Studies; Educational Status; Female; Humans; Incidence; Middle Aged; Mozambique; Obesity; Prevalence; Risk Assessment; Risk Factors; Young Adult; hormone receptor; adult; Africa south of the Sahara; aged; Article; birth; body height; body mass; body weight; breast cancer; cancer risk; case control study; cohort analysis; confidence interval; controlled study; educational status; female; human; major clinical study; middle aged; Mozambique; risk factor; tumor classification; World Health Organization; breast; breast tumor; fine needle aspiration biopsy; incidence; Mozambique; obesity; pathology; prevalence; risk assessment; risk factor; very elderly; young adult
Campos de estudo
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Citar a publicação
Brandão M,Guisseve A,Damasceno A,Bata G,Silva C,Alberto M,Ferro J,Garcia C,Zaqueu C,Lorenzoni C,Leitão D,Soares O,Gudo A,Schmitt F,Morais S,Tulsidás S,Carrilho C,Lunet N. Risk Factors for Breast Cancer, Overall and by Tumor Subtype, among Women from Mozambique, Sub-Saharan Africa. Cancer Epidemiol. Biomarkers Prev. 2021. 30. (6):p. 1250-1259. IF:4,090. (2).
