Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study

Autores da FMUP
Participantes de fora da FMUP
- Louis, R
- Giuliano, AFM
- Baiardini, I
- Braido, F
- Czarlewski, W
- Bedbrook, A
- Haahtela, T
- Valiulis, A
- Brussino, L
- Cecchi, L
- Cruz, AA
- Gemicioglu, B
- Fokkens, WJ
- Ivancevich, JC
- Klimek, L
- Kraxner, H
- Kuna, P
- Kupczyk, M
- Kvedariene, V
- Larenas-Linnemann, D
- Louis, R
- Nadif, R
- Niedoszytko, M
- Okamoto, Y
- Ollert, M
- Papadopoulos, NG
- Patella, V
- Pawankar, R
- Pham-Thi, N
- Pfaar, O
- Regateiro, FS
- Roche, N
- Rouadi, PW
- Samolinski, B
- Sastre, J
- Savoure, M
- Scichilone, N
- Sheikh, A
- Taborda-Barata, L
- ToPPila-Salmi, S
- Yorgancioglu, A
- Zidarn, M
- Anto, JM
- Zuberbier, T
- Canonica, GW
- Ventura, MT
- Petre, B
- Bousquet, J
Unidades de investigação
Abstract
BACKGROUND: EQ-5D-5L (EuroQOL, 5 Domains, 5 Levels) is a widely used health-related quality-of-life instrument, comprising 5 domains. However, it is not known how each domain is impacted by rhinitis or asthma control. OBJECTIVE: To assess the association between rhinitis or asthma control and the different EQ-5D-5L domains using data from the MASK-air mHealth app. METHODS: In this cross-sectional study, we assessed data from all MASK-air users (2015-2021; 24 countries). For the levels of each EQ-5D-5L domain, we assessed rhinitis and asthma visual analog scales (VASs) and the combined symptom-medication score (CSMS). We built ordinal multivariable models assessing the adjusted association between VAS/CSMS values and the levels of each EQ-5D-5L domain. Finally, we compared EQ-5D-5L data from users with rhinitis and self-reported asthma with data from users with rhinitis alone. RESULTS: We assessed 5354 days from 3092 users. We observed an association between worse control of rhinitis or asthma (higher VASs and CSMS) and worse EQ-5D-5L levels. In multivariable models, all VASs and the CSMS were associated with higher levels of pain/discomfort and daily activities. For anxiety/depression, the association was mostly observed for rhinitis-related tools (VAS nose, VAS global, and CSMS), although the presence of self-reported asthma was also associated with worse anxiety/depression. Worse mobility ("walking around") was particularly associated with VAS asthma and with the presence of asthma.CONCLUSIONS: A worse rhinitis control and a worse asthma control are associated with higher EQ-5D-5L levels, particularly regarding pain/discomfort and activity impairment. Worse rhinitis control is associated with worse anxiety/depression, and poor asthma control with worse mobility. (c) 2023 American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:3742-51)
Copyright © 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 2213-2198, 2213-2201
- Tipo:
- Article
- Páginas:
- 3742-37519
- Link para outro recurso:
- www.scopus.com
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE Elsevier
Citações Recebidas na Scopus: 7
Documentos
- Não há documentos
Filiações
Keywords
- Allergic rhinitis; Asthma; Mobile health; Quality of life
Campos de estudo
Financiamento
Proyectos asociados
Prevalence and Characterisation of Asthma Patients According to Disease Severity in Portugal (EPI-ASTHMA) - NCT05169619
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (EPI-ASTHMA) . AstraZeneca . 2021
Effect of a Mobile App on Improving Asthma Control in Adolescents and Adults With Persistent Asthma: A Pilot Randomized Multicentre, Superiority Clinical Trial (mINSPIRERS) - NCT05129527
Investigador Principal: João de Almeida Lopes da Fonseca
Ensaio Clínico Académico (mINSPIRERS) . 2021
Utilização em estudos observacionais do Registo de Asma Grave Portugal.
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Observacional Académico (RAG) . 2020
Clinical Research Collaboration Severe Heterogenous Asthma Research collaboration, Patient-centered (CRC SHARP).
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (SHARP) . European Respiratory Society . 2021
Multidimensional phenotyping of severe asthma patients and its impact on disease control and therapeutic response - analysis from the Portuguese Severe Asthma Registry.
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (RAG-SPP-GSK) . SPPneumologia . 2022
BREATHE - An oBservational, pRimary data study to characterize severe AsThma pHenotypes and assEss disease burden across the EUCAN region.
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Observacional (RAG-AZ-BREATHE) . AstraZeneca . 2022
Seroprevalence of SARS-CoV-2 and assessment of epidemiologic determinants in Portuguese municipal workers
Investigador Principal: Bernardo Manuel De Sousa Pinto
Estudo Clínico Académico (SARS-CoV-2) . 2021
Efficiency in Spine Care ? Assessing outcomes and costs to inform healthcare improvement
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2022
Use of secondary data, health technology assessment methods and economic modelling applied to penicillin allergy
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2020
Using different data sources for the identification of asthma patients and those at high risk of adverse outcomes
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2020
Phenotypes of Chronic Diseases of the Airways: Towards Multidimensional Data -Driven Profiling
Investigador Principal: João de Almeida Lopes da Fonseca
Estudo Clínico Académico . 2020
Citar a publicação
Sousa B,Louis R,Rodrigues J,Giuliano A,Baiardini I,Braido F,Czarlewski W,Bedbrook A,Haahtela T,Valiulis A,Brussino L,Cecchi L,Cruz AA,Gemicioglu B,Fokkens WJ,Ivancevich JC,Klimek L,Kraxner H,Kuna P,Kupczyk M,Kvedariene V,Larenas D,Louis R,Nadif R,Niedoszytko M,Okamoto Y,Ollert M,Papadopoulos NG,Patella V,Pawankar R,Pham N,Pfaar O,Regateiro FS,Roche N,Rouadi PW,Samolinski B,Sastre J,Savoure M,Scichilone N,Sheikh A,Taborda L,ToPPila S,Yorgancioglu A,Zidarn M,Anto JM,Zuberbier T,Canonica GW,Ventura MT,Fonseca JA,Petre B,Bousquet J. Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study. J. Allergy Clin. Immunol. Pract. 2023. 11. (12):p. 3742-37519. IF:9,400. (1).