Portal de investigação
Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015-2018
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Bandeira, T
- Carmo, M
- Lopes, H
- Gomes, C
- Martins, M
- Guzman, C
- Bangert, M
- Rodrigues, F
- Januario, G
- Tome, T
Unidades de investigação
Abstract
Background Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory infection (ALRI) in young children and is of considerable burden on healthcare systems. Our study aimed to evaluate ALRI hospitalizations related to RSV in children in Portugal. Methods We reviewed hospitalizations potentially related to RSV in children aged <5 years from 2015 to 2018, using anonymized administrative data covering all public hospital discharges in mainland Portugal. Three case definitions were considered: (a) RSV-specific, (b) (a) plus unspecified acute bronchiolitis (RSV-specific & Bronchiolitis), and (c) (b) plus unspecified ALRI (RSV-specific & ALRI). Results A total of 9697 RSV-specific hospitalizations were identified from 2015 to 2018-increasing to 26 062 for RSV-specific & ALRI hospitalizations-of which 74.7% were during seasons 2015/2016-2017/2018 (November-March). Mean hospitalization rates per season were, for RSV-specific, RSV-specific & Bronchiolitis, and RSV-specific & ALRI, respectively, 5.6, 9.4, and 11.8 per 1000 children aged <5 years and 13.4, 22.5, and 25.9 in children aged <2 years. Most RSV-specific hospitalizations occurred in healthy children (94.9%) and in children aged <2 years (96.3%). Annual direct costs of euro2.4 million were estimated for RSV-specific hospitalizations-rising to euro5.1 million for RSV-specific & ALRI-mostly driven by healthy children (87.6%). Conclusion RSV is accountable for a substantial number of hospitalizations in children, especially during their first year of life. Hospitalizations are mainly driven by healthy children. The variability of the potential RSV burden across case definitions highlights the need for a universal RSV surveillance system to guide prevention strategies.
Dados da publicação
- ISSN/ISSNe:
- 1750-2640, 1750-2659
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.1111/irv.13066
- Link para outro recurso:
- www.scopus.com
Influenza and other Respiratory Viruses Wiley-Blackwell Publishing Ltd
Citações Recebidas na Web of Science: 7
Citações Recebidas na Scopus: 16
Documentos
- Não há documentos
Filiações
Keywords
- administrative data; burden; hospitalizations; lower respiratory infection; Portugal; respiratory syncytial virus
Financiamento
Proyectos asociados
Hospitalizations for Varicella in children and adolescents in Portugal: 2000 to 2015
Investigador Principal: Maria Inês Ferreira Agueda de Azevedo
Estudo Clínico Académico (Varicella) . 2020
Pulmonary Auscultation using Mobile Devices - Feasibility Study in Respiratory Diseases
Investigador Principal: Maria Inês Ferreira Agueda de Azevedo
Estudo Clínico Académico . 2021
Management of pediatric patients with complicated pneumonia in Portugal, 2000-2015: trends over time and according to regions
Investigador Principal: Maria Inês Ferreira Agueda de Azevedo
Estudo Clínico Académico (Pediatric pneumonia) . 2022
Citar a publicação
Bandeira T,Carmo M,Lopes H,Gomes C,Martins M,Guzman C,Bangert M,Rodrigues F,Januario G,Tome T,Azevedo I. Burden and severity of children's hospitalizations by respiratory syncytial virus in Portugal, 2015-2018. Influ. Other Respir. Viruses. 2023. 17. (1):e13066. IF:4,400. (2).
