Portal de investigação
Development and validation of combined symptom-medication scores for allergic rhinitis*
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Jutel, M
- Agache, I
- Canonica, GW
- Czarlewski, W
- Papadopoulos, NG
- Bergmann, KC
- Devillier, P
- Laune, D
- Klimek, L
- Anto, A
- Anto, JM
- Eklund, P
- Bedbrook, A
- Bosnic Anticevich, S
- Brough, HA
- Brussino, L
- Cardona, V
- Casale, T
- Cecchi, L
- Charpin, D
- Chivato, T
- Costa, E.
- Cruz, AA
- Dramburg, S
- Durham, SR
- De Feo, G
- van Wijk, RG
- Fokkens, WJ
- Gemicioglu, B
- Haahtela, T
- Illario, M
- Ivancevich, JC
- Kvedariene, V
- Kuna, P
- Larenas Linnemann, DE
- Makris, M
- Mathieu Dupas, E
- Melen, E
- Morais Almeida, M
- Mösges, R
- Mullol, J
- Nadeau, KC
- Nhan, PH
- O'Hehir, R
- Regateiro, FS
- Reitsma, S
- Samolinski, B
- Sheikh, A
- Stellato, C
- Todo Bom, A
- Tomazic, PV
- Toppila Salmi, S
- Valero, A
- Valiulis, A
- Ventura, MT
- Wallace, D
- Waserman, S
- Yorgancioglu, A
- Vries, G
- Eerd, M
- Zieglmayer, P
- Zuberbier, T
- Pfaar, O
- Bousquet, J
Unidades de investigação
Abstract
Background Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air(R) app to generate and validate hypothesis- and data-driven CSMSs. Methods We used MASK-air(R) data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air(R) data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air(R), and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results We assessed 317,176 days of MASK-air(R) use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials.
Dados da publicação
- ISSN/ISSNe:
- 0105-4538, 1398-9995
- Tipo:
- Article
- Páginas:
- 2147-2162
- DOI:
- 10.1111/all.15199
- PubMed:
- 34932829
- Link para outro recurso:
- www.scopus.com
ALLERGY Wiley-Blackwell Publishing Ltd
Citações Recebidas na Web of Science: 28
Citações Recebidas na Scopus: 44
Documentos
- Não há documentos
Filiações
Keywords
- medication score; quality-of-life; rhinitis; symptom score; work
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