Portal de investigação
Development and validation of combined symptom-medication scores for allergic rhinitis*
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Jutel, M
- Agache, I
- Canonica, GW
- Czarlewski, W
- Papadopoulos, NG
- Bergmann, KC
- Devillier, P
- Laune, D
- Klimek, L
- Anto, A
- Anto, JM
- Eklund, P
- Bedbrook, A
- Bosnic Anticevich, S
- Brough, HA
- Brussino, L
- Cardona, V
- Casale, T
- Cecchi, L
- Charpin, D
- Chivato, T
- Costa, E.
- Cruz, AA
- Dramburg, S
- Durham, SR
- De Feo, G
- van Wijk, RG
- Fokkens, WJ
- Gemicioglu, B
- Haahtela, T
- Illario, M
- Ivancevich, JC
- Kvedariene, V
- Kuna, P
- Larenas Linnemann, DE
- Makris, M
- Mathieu Dupas, E
- Melen, E
- Morais Almeida, M
- Mösges, R
- Mullol, J
- Nadeau, KC
- Nhan, PH
- O'Hehir, R
- Regateiro, FS
- Reitsma, S
- Samolinski, B
- Sheikh, A
- Stellato, C
- Todo Bom, A
- Tomazic, PV
- Toppila Salmi, S
- Valero, A
- Valiulis, A
- Ventura, MT
- Wallace, D
- Waserman, S
- Yorgancioglu, A
- Vries, G
- Eerd, M
- Zieglmayer, P
- Zuberbier, T
- Pfaar, O
- Bousquet, J
Unidades de investigação
Abstract
Background Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air(R) app to generate and validate hypothesis- and data-driven CSMSs. Methods We used MASK-air(R) data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air(R) data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air(R), and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results We assessed 317,176 days of MASK-air(R) use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials.
Dados da publicação
- ISSN/ISSNe:
- 0105-4538, 1398-9995
- Tipo:
- Article
- Páginas:
- 2147-2162
- DOI:
- 10.1111/all.15199
- Link para outro recurso:
- www.scopus.com
ALLERGY Wiley-Blackwell Publishing Ltd
Citações Recebidas na Web of Science: 28
Citações Recebidas na Scopus: 44
Documentos
- Não há documentos
Filiações
Keywords
- medication score; quality-of-life; rhinitis; symptom score; work
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Citar a publicação
Sousa B,Azevedo L,Jutel M,Agache I,Canonica GW,Czarlewski W,Papadopoulos NG,Bergmann KC,Devillier P,Laune D,Klimek L,Anto A,Anto JM,Eklund P,Almeida R,Bedbrook A,Bosnic S,Brough HA,Brussino L,Cardona V,Casale T,Cecchi L,Charpin D,Chivato T,Costa E,Cruz AA,Dramburg S,Durham SR,De Feo G,van RG,Fokkens WJ,Gemicioglu B,Haahtela T,Illario M,Ivancevich JC,Kvedariene V,Kuna P,Larenas DE,Makris M,Mathieu E,Melen E,Morais M,Mösges R,Mullol J,Nadeau KC,Nhan PH,O'Hehir R,Regateiro FS,Reitsma S,Samolinski B,Sheikh A,Stellato C,Todo A,Tomazic PV,Toppila S,Valero A,Valiulis A,Ventura MT,Wallace D,Waserman S,Yorgancioglu A,Vries G,Eerd M,Zieglmayer P,Zuberbier T,Pfaar O,Fonseca J,Bousquet J. Development and validation of combined symptom-medication scores for allergic rhinitis*. Allergy. 2022. 77. (7):p. 2147-2162. IF:12,400. (1).
