Urocortins as biomarkers in cardiovascular disease

Autores da FMUP

• Joaquim Adelino Correia Ferreira Leite Moreira

  Autor

• Carmen Dulce Da Silveira Brás Silva Ribeiro

  Autor

Participantes de fora da FMUP

• Vasconcelos, I
• Adao, R
• Rademaker, MT
• Fontes-Sousa, AP

Unidades de investigação

• Cirurgia e Fisiologia

• Laboratório Associado RISE- Rede de Investigação em Saúde

  

  Investigador

  Fernando Carlos De Landér Schmitt

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

The urocortins (Ucns) belong to the corticotropin-releasing factor (CRF) family of peptides and have multiple effects within the central nervous and the cardiovascular systems. With growing evidence indicating significant cardioprotective properties and cardiovascular actions of these peptides, the question arises as to whether the plasma profiles of the Ucns are altered in pathologic settings. While reports have shown conflicting results and findings have not been corroborated in multiple independent cohorts, it seems likely that plasma Ucn concentrations are elevated in multiple cardiovascular conditions. The degree of increase and accurate determination of circulating values of the Ucns requires further validation.

© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Keywords

• Animals; Biomarkers; Cardiovascular Diseases; Humans; Urocortins; urocortin; biological marker; urocortin; abdominal aortic aneurysm; acute heart infarction; Buerger disease; cardiovascular disease; comorbidity; coronary artery disease; heart failure; human; hypertension; maternal hypertension; non insulin dependent diabetes mellitus; obesity; pregnancy complication; pulmonary hypertension; Review; animal; blood; cardiovascular disease