Portal de investigação
Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Lipp, T
- Sahin, AA
- Aggelidis, X
- Arasi, S
- Barbalace, A
- Bourgoin, A
- Bregu, B
- Brighetti, MA
- Caeiro, E
- Sozmen, SC
- Caminiti, L
- Charpin, D
- Couto, M
- Businco, AD
- Dimier, C
- Dimou, MV
- Goksel, O
- Guvensen, A
- Hernandez, D
- Hoffmann, TM
- Jang, DT
- Kalpaklioglu, F
- Lame, B
- Llusar, R
- Makris, MP
- Mazon, A
- Mesonjesi, E
- Nieto, A
- Öztürk, A
- Pahus, L
- Pajno, GB
- Panasiti, I
- Papadopoulos, NG
- Pellegrini, E
- Pelosi, S
- Pereira, A.
- Pereira, M
- Pinar, M
- Potapova, E
- Priftanji, A
- Psarros, F
- Sackesen, C
- Sfika, I
- Suarez, J
- Thibaudon, M
- Travaglini, A
- Tripodi, S
- Verdier, V
- Villella, V
- Xepapadaki, P
- Yazici, D
- Matricardi, PM
- Dramburg, S
Unidades de investigação
Abstract
Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS. Methods As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10-60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing. Results Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR-10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono-sensitized patients reporting a food reaction (p < 0.073). Conclusions PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS-associated characteristics.
© 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Dados da publicação
- ISSN/ISSNe:
- 0105-4538, 1398-9995
- Tipo:
- Article
- Páginas:
- 3041-3052
- DOI:
- 10.1111/all.14742
- Link para outro recurso:
- www.scopus.com
ALLERGY Wiley-Blackwell Publishing Ltd
Citações Recebidas na Web of Science: 13
Citações Recebidas na Scopus: 22
Documentos
- Não há documentos
Filiações
Keywords
- oral allergy syndrome; panallergen; pollen food allergy syndrome; seasonal allergic rhinitis; Southern Europe
Campos de estudo
Financiamento
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Citar a publicação
Lipp T,Sahin AA,Aggelidis X,Arasi S,Barbalace A,Bourgoin A,Bregu B,Brighetti MA,Caeiro E,Sozmen SC,Caminiti L,Charpin D,Couto M,Delgado L,Businco AD,Dimier C,Dimou MV,Fonseca JA,Goksel O,Guvensen A,Hernandez D,Hoffmann TM,Jang DT,Kalpaklioglu F,Lame B,Llusar R,Makris MP,Mazon A,Mesonjesi E,Nieto A,Öztürk A,Pahus L,Pajno GB,Panasiti I,Papadopoulos NG,Pellegrini E,Pelosi S,Pereira A,Pereira M,Pinar M,Potapova E,Priftanji A,Psarros F,Sackesen C,Sfika I,Suarez J,Thibaudon M,Travaglini A,Tripodi S,Verdier V,Villella V,Xepapadaki P,Yazici D,Matricardi PM,Dramburg S. Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study. Allergy. 2021. 76. (10):p. 3041-3052. IF:14,710. (1).
