Portal de investigação
Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Bousquet, J
- Czarlewski, W
- Zuberbier, T
- Mullol, J
- Blain, H
- Cristol, JP
- De la Torre, R
- Lozano, NP
- Le Moing, V
- Bedbrook, A
- Agache, I
- Akdis, CA
- Canonica, GW
- Cruz, AA
- Fiocchi, A
- Fonseca, S
- Gemicioglu, B
- Haahtela, T
- Iaccarino, G
- Ivancevich, JC
- Jutel, M
- Klimek, L
- Kraxner, H
- Kuna, P
- Larenas-Linnemann, DE
- Martineau, A
- Melén, E
- Okamoto, Y
- Papadopoulos, NG
- Pfaar, O
- Regateiro, FS
- Reynes, J
- Rolland, Y
- Rouadi, PW
- Samolinski, B
- Sheikh, A
- Toppila-Salmi, S
- Valiulis, A
- Choi, HJ
- Kim, HJ
- Anto, JM
Unidades de investigação
Abstract
In this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
© 2021 S. Karger AG, Basel.
Dados da publicação
- ISSN/ISSNe:
- 1423-0097, 1018-2438
- Tipo:
- Review
- Páginas:
- 324-338
- DOI:
- 10.1159/000514204
- Link para outro recurso:
- www.scopus.com
International Archives of Allergy and Immunology S. Karger AG
Citações Recebidas na Web of Science: 25
Citações Recebidas na Scopus: 32
Documentos
- Não há documentos
Filiações
Keywords
- COVID-19; Nrf2; TRAP-1; Broccoli; Pungent foods; Cough challenge
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Citar a publicação
Bousquet J,Czarlewski W,Zuberbier T,Mullol J,Blain H,Cristol JP,De la Torre R,Lozano NP,Le V,Bedbrook A,Agache I,Akdis CA,Canonica GW,Cruz AA,Fiocchi A,Fonseca JA,Fonseca S,Gemicioglu B,Haahtela T,Iaccarino G,Ivancevich JC,Jutel M,Klimek L,Kraxner H,Kuna P,Larenas DE,Martineau A,Melén E,Okamoto Y,Papadopoulos NG,Pfaar O,Regateiro FS,Reynes J,Rolland Y,Rouadi PW,Samolinski B,Sheikh A,Toppila S,Valiulis A,Choi HJ,Kim HJ,Anto JM. Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19. Int. Arch. Allergy Immunol. 2021. 182(4):p. 324-338. IF:3,767. (3).
