Portal de investigação
Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Alves-Correia, M
- Mendes, S
- Rodrigues, JCC
- Carvalho, J
- Costa, A
- Silva, A
- Teixeira, MF
- Ferreira-Magalhaes, M
- Alves, RR
- Moreira, AS
- Fernandes, RM
- Ferreira, R
- Pinto, PL
- Neuparth, N
- Bom, AT
- Cálix, MJ
- Ferreira, T
- Gomes, J
- Vidal, C
- Mendes, A
- Vasconcelos, MJ
- Silva, PM
- Ferraz, J
- Morête, A
- Pinto, CS
- Santos, N
- Loureiro, CC
- Arrobas, A
- Marques, ML
- Lozoya, C
- Lopes, C
- Cardia, F
- Loureiro, CC
- Câmara, R
- Vieira, I
- da Silva, S
- Silva, E
- Rodrigues, N
Unidades de investigação
Abstract
We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
Dados da publicação
- ISSN/ISSNe:
- 1661-7827, 1660-4601
- Tipo:
- Article
- Páginas:
- 1-11
- PubMed:
- 33498858
- Link para outro recurso:
- www.scopus.com
International Journal of Environmental Research and Public Health Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 6
Documentos
- Não há documentos
Filiações
Keywords
- asthma; adolescents; phenotypes; clustering; longitudinal studies; latent class analysis
Financiamento
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