Portal de investigação
Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Faria, B
- da Costa, MG
- Lima, C
- Willems, L
- Brandwijk, R
- Berger, SP
- Daha, MR
- Seelen, MA
- Poppelaars, F
Unidades de investigação
Abstract
Introduction Various studies have reported the importance of complement regulators in preventing mesothelial damage during peritoneal dialysis (PD). Its assessment, however, is limited in clinical practice due to the lack of easy access to the peritoneal membrane. Recently, a soluble form of the complement regulatory protein CD59 (sCD59) has been described. We therefore aimed to investigate the role of sCD59 in PD. Methods Plasma sCD59 was measured in 48 PD patients, 41 hemodialysis patients, 15 non-dialysis patients with chronic kidney disease and 14 healthy controls by ELISA (Hycult; HK374-02). Additionally, sCD59 and sC5b-9 were assessed in the peritoneal dialysate. Results sCD59 and sC5b-9 were detectable in the peritoneal dialysate of all patients, and marginally correlated (r = 0.27, P = 0.06). Plasma sCD59 levels were significantly higher in PD patients than in patients with chronic kidney disease and healthy controls, but did not differ from hemodialysis patients. During follow-up, 19% of PD patients developed peritoneal membrane failure and 27% of PD patients developed loss of residual renal function. In adjusted models, increased sCD59 levels in the dialysate (HR 3.44, 95% CI 1.04-11.40, P = 0.04) and in plasma (HR 1.08, 95% CI 1.01-1.17, P = 0.04) were independently associated with the occurrence of peritoneal membrane failure. Higher plasma levels of sCD59 were also associated with loss of residual renal function (HR 1.10, 95% CI 1.04-1.17, P < 0.001). Conclusions Our study suggests that sCD59 has potential as a biomarker to predict peritoneal membrane function and loss of residual renal function in PD, thereby offering a tool to improve patient management.
Dados da publicação
- ISSN/ISSNe:
- 1724-6059, 1121-8428
- Tipo:
- Article
- Páginas:
- 801-810
- Link para outro recurso:
- www.scopus.com
Journal of Nephrology Wichtig Publishing Srl
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 3
Documentos
- Não há documentos
Filiações
Keywords
- Complement; Dialysis; Chronic kidney disease; Innate immunity
Proyectos asociados
Rituximab na terapêutica da nefropatia membranosa
Investigador Principal: Manuel Jesus Falcão Pestana Vasconcelos
Estudo Clínico Académico (Rituximab) . 2020
Citar a publicação
Faria B,da MG,Lima C,Willems L,Brandwijk R,Berger SP,Daha MR,Pestana M,Seelen MA,Poppelaars F. Soluble CD59 in peritoneal dialysis: a potential biomarker for peritoneal membrane function. J. Nephrol. 2021. 34. (3):p. 801-810. IF:4,393. (2).
