Myocardial Edema: an Overlooked Mechanism of Septic Cardiomyopathy?

Autores da FMUP

• Francisco Aguiar Vasques Novoa Faria

  Autor

• Nuno Teodoro V. Reis Bettencourt Sousa

  Autor

• José Pedro Lopes Nunes

  Autor

• Maria De Fátima Machado Henriques Carneiro

  Autor

• José Artur Osório De Carvalho Paiva

  Autor

• Joaquim Adelino Correia Ferreira Leite Moreira

  Autor

• Roberto Liberal Fernandes Roncon Albuquerque

  Autor

Participantes de fora da FMUP

• Laundos, TL
• Madureira, A
• Pinto-do-?, P.
• Nascimento, D.

Unidades de investigação

• Cirurgia e Fisiologia

• Medicina

• Patologia

• RISE-Health

  

  Investigador

  Fernando Carlos De Landér Schmitt

Abstract

Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury are still poorly understood. Herein, new clinical and histological evidence is provided suggesting an association of myocardial edema formation with tissue injury and subsequent remodeling in septic shock patients. This preliminary data supports myocardial edema as a potentially relevant and largely unexplored mechanism of human septic cardiomyopathy.

Keywords

• Myocardial dysfunction; myocardial edema; septic shock; troponin I