Portal de investigação
Empagliflozin in Heart Failure with a Preserved Ejection Fraction
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Anker, SD
- Butler, J
- Filippatos, G
- Bocchi, E
- Böhm, M
- Brunner-La Rocca, HP
- Choi, DJ
- Chopra, V
- Chuquiure-Valenzuela, E
- Giannetti, N
- Gomez-Mesa, JE
- Janssens, S
- Januzzi, JL
- Gonzalez-Juanatey, JR
- Merkely, B
- Nicholls, SJ
- Perrone, SV
- Piña, IL
- Ponikowski, P
- Senni, M
- Sim, D
- Spinar, J
- Squire, I
- Taddei, S
- Tsutsui, H
- Verma, S
- Vinereanu, D
- Zhang, J
- Carson, P
- Lam, CSP
- Marx, N
- Zeller, C
- Sattar, N
- Jamal, W
- Schnaidt, S
- Schnee, JM
- Brueckmann, M
- Pocock, SJ
- Zannad, F
- Packer, M
- EMPEROR Preserved Trial
Unidades de investigação
Abstract
BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P<0.001). This effect was mainly related to a lower risk of hospitalization for heart failure in the empagliflozin group. The effects of empagliflozin appeared consistent in patients with or without diabetes. The total number of hospitalizations for heart failure was lower in the empagliflozin group than in the placebo group (407 with empagliflozin and 541 with placebo; hazard ratio, 0.73; 95% CI, 0.61 to 0.88; P<0.001). Uncomplicated genital and urinary tract infections and hypotension were reported more frequently with empagliflozin. CONCLUSIONS Empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.
Dados da publicação
- ISSN/ISSNe:
- 0028-4793, 1533-4406
- Tipo:
- Article
- Páginas:
- 1451-1461
New England Journal of Medicine Massachussetts Medical Society
Citações Recebidas na Web of Science: 1,738
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Filiações
Financiamento
Proyectos asociados
Dapagliflozin, Spironolactone or Both for HFpEF (SOGALDI-PEF) - NCT05676684
Investigador Principal: João Pedro Melo Marques Pinho Ferreira
Ensaio Clínico Académico (SOGALDI-PEF) . AstraZeneca . 2022
Citar a publicação
Anker SD,Butler J,Filippatos G,Ferreira JP,Bocchi E,Böhm M,Brunner HP,Choi DJ,Chopra V,Chuquiure E,Giannetti N,Gomez JE,Janssens S,Januzzi JL,Gonzalez JR,Merkely B,Nicholls SJ,Perrone SV,Piña IL,Ponikowski P,Senni M,Sim D,Spinar J,Squire I,Taddei S,Tsutsui H,Verma S,Vinereanu D,Zhang J,Carson P,Lam CSP,Marx N,Zeller C,Sattar N,Jamal W,Schnaidt S,Schnee JM,Brueckmann M,Pocock SJ,Zannad F,Packer M,EMPEROR T. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. New Engl. J. Med. 2021. 385. (16):p. 1451-1461. IF:176,079. (1).
