Portal de investigação
Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Butler, J
- Filippatos, G
- Siddiqi, TJ
- Brueckmann, M
- Böhm, M
- Chopra, VK
- Januzzi, JL
- Kaul, S
- Piña, IL
- Ponikowski, P
- Shah, SJ
- Senni, M
- Vedin, O
- Verma, S
- Peil, B
- Pocock, SJ
- Zannad, F
- Packer, M
- Anker, SD
Unidades de investigação
Abstract
BACKGROUND: Patients with heart failure with preserved ejection fraction have significant impairment in health-related quality of life. In the EMPEROR-Preserved trial (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction), we evaluated the efficacy of empagliflozin on health-related quality of life in patients with heart failure with preserved ejection fraction and whether the clinical benefit observed with empagliflozin varies according to baseline health status. METHODS: Health-related quality of life was measured with the Kansas City Cardiomyopathy Questionnaire (KCCQ) at baseline and 12, 32, and 52 weeks. Patients were divided by baseline KCCQ Clinical Summary Score (CSS) tertiles, and the effect of empagliflozin on outcomes was examined. The effect of empagliflozin on KCCQ-CSS, Total Symptom Score, and Overall Summary Score was evaluated. Responder analyses were performed to compare the odds of improvement and deterioration in KCCQ related to treatment with empagliflozin. RESULTS: The effect of empagliflozin on reducing the risk of time to cardiovascular death or heart failure hospitalization was consistent across baseline KCCQ-CSS tertiles (hazard ratio, 0.83 [95% CI, 0.69-1.00], 0.70 [95% CI, 0.55-0.88], and 0.82 [95% CI, 0.62-1.08] for scores <62.5, 62.5-83.3, and >= 83.3, respectively; P trend=0.77). Similar results were seen for total heart failure hospitalizations. Patients treated with empagliflozin had significant improvement in KCCQ-CSS versus placebo (+1.03, +1.24, and +1.50 at 12, 32, and 52 weeks, respectively; P<0.01); similar results were seen for Total Symptom Score and Overall Summary Score. At 12 weeks, patients on empagliflozin had higher odds of improvement >= 5 points (odds ratio, 1.23 [95% CI, 1.10-1.37]), >= 10 points (odds ratio, 1.15 [95% CI, 1.03-1.27]), and >= 15 points (odds ratio, 1.13 [95% CI, 1.02-1.26]) and lower odds of deterioration >= 5 points in KCCQ-CSS (odds ratio, 0.85 [95% CI, 0.75-0.97]). A similar pattern was seen at 32 and 52 weeks, and results were consistent for Total Symptom Score and Overall Summary Score. CONCLUSIONS: In patients with heart failure with preserved ejection fraction, empagliflozin reduced the risk for major heart failure outcomes across the range of baseline KCCQ scores. Empagliflozin improved health-related quality of life, an effect that appeared early and was sustained for at least 1 year.
Dados da publicação
- ISSN/ISSNe:
- 0009-7322, 1524-4539
- Tipo:
- Article
- Páginas:
- 184-193
- Link para outro recurso:
- www.scopus.com
Circulation Lippincott Williams and Wilkins Ltd.
Citações Recebidas na Web of Science: 86
Citações Recebidas na Scopus: 124
Documentos
- Não há documentos
Filiações
Keywords
- empagliflozin; health status; heart failure, diastolic; quality of life
Campos de estudo
Financiamento
Proyectos asociados
Dapagliflozin, Spironolactone or Both for HFpEF (SOGALDI-PEF) - NCT05676684
Investigador Principal: João Pedro Melo Marques Pinho Ferreira
Ensaio Clínico Académico (SOGALDI-PEF) . AstraZeneca . 2022
Citar a publicação
Butler J,Filippatos G,Siddiqi TJ,Brueckmann M,Böhm M,Chopra VK,Ferreira JP,Januzzi JL,Kaul S,Piña IL,Ponikowski P,Shah SJ,Senni M,Vedin O,Verma S,Peil B,Pocock SJ,Zannad F,Packer M,Anker SD. Empagliflozin, Health Status, and Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial. Circulation. 2022. 145. (3):p. 184-193. IF:37,800. (1).
