Portal de investigação
Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Biegus, J
- Voors, AA
- Collins, SP
- Kosiborod, MN
- Teerlink, JR
- Angermann, CE
- Tromp, J
- Nassif, ME
- Psotka, MA
- Brueckmann, M
- Salsali, A
- Blatchford, JP
- Ponikowski, P
Unidades de investigação
Abstract
Aims Effective and safe decongestion remains a major goal for optimal management of patients with acute heart failure (AHF). The effects of the sodium-glucose cotransporter 2 inhibitor empagliflozin on decongestion-related endpoints in the EMPULSE trial (NCT0415775) were evaluated. Methods and results A total of 530 patients hospitalized for AHF were randomized 1:1 to either empagliflozin 10 mg once daily or placebo for 90 days. The outcomes investigated were: weight loss (WL), WL adjusted for mean daily loop diuretic dose (WL-adjusted), area under the curve of change from baseline in N-terminal pro-B-type natriuretic peptide levels, hemoconcentration, and clinical congestion score after 15, 30, and 90 days of treatment. Compared with placebo, patients treated with empagliflozin demonstrated significantly greater reductions in all studied markers of decongestion at all time-points, adjusted mean differences (95% confidence interval) at Days 15, 30, and 90 were: for WL -1.97 (-2.86, -1.08), -1.74 (-2.73, -0.74); -1.53 (-2.75, -0.31) kg; for WL-adjusted: -2.31 (-3.77, -0.85), -2.79 (-5.03, -0.54), -3.18 (-6.08, -0.28) kg/40 mg furosemide i.v. or equivalent; respectively (all P < 0.05). Greater WL at Day 15 (i.e. above the median WL in the entire population) was associated with significantly higher probability for clinical benefit at Day 90 (hierarchical composite of all-cause death, heart failure events, and a 5-point or greater difference in Kansas City Cardiomyopathy Questionnaire total symptom score change from baseline to 90 days) with the win ratio of 1.75 (95% confidence interval 1.37, 2.23; P < 0.0001). Conclusion Initiation of empagliflozin in patients hospitalized for AHF resulted in an early, effective and sustained decongestion which was associated with clinical benefit at Day 90.
Dados da publicação
- ISSN/ISSNe:
- 1522-9645, 0195-668X
- Tipo:
- Article
- Páginas:
- 41-50
- Link para outro recurso:
- www.scopus.com
European Heart Journal Oxford University Press
Citações Recebidas na Web of Science: 51
Citações Recebidas na Scopus: 103
Documentos
- Não há documentos
Filiações
Keywords
- SGLT-2 inhibitor; Decongestion; Acute heart failure; Empagliflozin
Financiamento
Proyectos asociados
Dapagliflozin, Spironolactone or Both for HFpEF (SOGALDI-PEF) - NCT05676684
Investigador Principal: João Pedro Melo Marques Pinho Ferreira
Ensaio Clínico Académico (SOGALDI-PEF) . AstraZeneca . 2022
Citar a publicação
Biegus J,Voors AA,Collins SP,Kosiborod MN,Teerlink JR,Angermann CE,Tromp J,Ferreira JP,Nassif ME,Psotka MA,Brueckmann M,Salsali A,Blatchford JP,Ponikowski P. Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial. Eur. Heart J. 2023. 44. (1):p. 41-50. IF:39,300. (1).
