Portal de investigação
Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Penna, C
- Andreadou, I
- Aragno, M
- Beauloye, C
- Bertrand, L
- Lazou, A
- Bell, R
- Zuurbier, CJ
- Pagliaro, P
- Hausenloy, DJ
Unidades de investigação
Abstract
Diabetic patients are at increased risk of developing coronary artery disease and experience worse clinical outcomes following acute myocardial infarction. Novel therapeutic strategies are required to protect the myocardium against the effects of acute ischaemia-reperfusion injury (IRI). These include one or more brief cycles of non-lethal ischaemia and reperfusion prior to the ischaemic event (ischaemic preconditioning [IPC]) or at the onset of reperfusion (ischaemic postconditioning [IPost]) either to the heart or to extracardiac organs (remote ischaemic conditioning [RIC]). Studies suggest that the diabetic heart is resistant to cardioprotective strategies, although clinical evidence is lacking. We overview the available animal models of diabetes, investigating acute myocardial IRI and cardioprotection, experiments investigating the effects of hyperglycaemia on susceptibility to acute myocardial IRI, the response of the diabetic heart to cardioprotective strategies e.g. IPC, IPost and RIC. Finally we highlight the effects of anti-hyperglycaemic agents on susceptibility to acute myocardial IRI and cardioprotection.
Dados da publicação
- ISSN/ISSNe:
- 1476-5381, 0007-1188
- Tipo:
- Review
- Páginas:
- 5312-5335
- DOI:
- 10.1111/bph.14993
- Link para outro recurso:
- www.scopus.com
British Journal of Pharmacology Wiley-Blackwell
Citações Recebidas na Web of Science: 48
Citações Recebidas na Scopus: 70
Documentos
- Não há documentos
Filiações
Keywords
- PERCUTANEOUS CORONARY INTERVENTION; ARTERY-BYPASS SURGERY; HEART-FAILURE; INFARCT SIZE; MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; CONCISE GUIDE; FATTY RATS; TYPE-2; PROTECTION
Financiamento
Proyectos asociados
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Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Citar a publicação
Penna C,Andreadou I,Aragno M,Beauloye C,Bertrand L,Lazou A,Falcao I,Bell R,Zuurbier CJ,Pagliaro P,Hausenloy DJ. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols. Br. J. Pharmacol. 2020. 177(23):p. 5312-5335. IF:8,739. (1).
