Portal de investigação
International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries
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Autores da FMUP
Participantes de fora da FMUP
- Hocquette, A
- Durox, M
- Wood, R
- Klungsoyr, K
- Szamotulska, K
- Berrut, S
- Rihs, T
- Kyprianou, T
- Sakkeus, L
- Lecomte, A
- Zile, I
- Alexander, S
- Klimont, J
- Gatt, M
- Isakova, J
- Blondel, B
- Gissler, M
- Zeitlin, J
Unidades de investigação
Abstract
Background: To inform the on-going debate about the use of universal prescriptive versus national intrauter-ine growth charts, we compared perinatal mortality for small and large-for-gestational-age (SGA/LGA) infants according to international and national charts in Europe. Methods: We classified singleton births from 33 to 42 weeks of gestation in 2010 and 2014 from 15 countries (N = 1,475,457) as SGA (birthweight <10th percentile) and LGA (>90th percentile) using the international Intergrowth-21st newborn standards and national charts based on the customised charts methodology. We computed sex-adjusted odds ratios (aOR) for stillbirth, neonatal and extended perinatal mortality by this classification using multilevel models. Findings: SGA and LGA prevalence using national charts were near 10% in all countries, but varied according to international charts with a north to south gradient (3.0% to 10.1% and 24.9% to 8.0%, respectively). Com-pared with appropriate for gestational age (AGA) infants by both charts, risk of perinatal mortality was increased for SGA by both charts (aOR[95% confidence interval (CI)]=6.1 [5.6-6.7]) and infants reclassified by international charts from SGA to AGA (2.7 [2.3-3.1]), but decreased for those reclassified from AGA to LGA (0.6 [0.4-0.7]). Results were similar for stillbirth and neonatal death. Interpretation: Using international instead of national charts in Europe could lead to growth restricted infants being reclassified as having normal growth, while infants with low risks of mortality could be reclassified as having excessive growth.
Dados da publicação
- ISSN/ISSNe:
- 2666-7762, 2666-7762
- Tipo:
- Article
- Páginas:
- -
Lancet Regional Health-Europe ELSEVIER
Citações Recebidas na Web of Science: 40
Documentos
- Não há documentos
Filiações
Keywords
- fetal growth; small for gestational age; large for gestational age; fetal growth charts
Financiamento
Proyectos asociados
Estudo dos factores de risco cardiovascular numa população adulta da Província do Bengo, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2019
Citar a publicação
Hocquette A,Durox M,Wood R,Klungsoyr K,Szamotulska K,Berrut S,Rihs T,Kyprianou T,Sakkeus L,Lecomte A,Zile I,Alexander S,Klimont J,Barros H,Gatt M,Isakova J,Blondel B,Gissler M,Zeitlin J. International versus national growth charts for identifying small and large-for-gestational age newborns: A population-based study in 15 European countries. Lancet. Reg. Health. Eur. 2021. 8. 100167.
