Portal de investigação
Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Ferro, A
- Rosato, V
- Rota, M
- Costa, AR
- Morais, S
- Pelucchi, C
- Johnson, KC
- Hu, JF
- Palli, D
- Ferraroni, M
- Zhang, ZF
- Bonzi, R
- Yu, GP
- Lopez Carrillo, L
- Tsugane, S
- Hamada, GS
- Hidaka, A
- Zaridze, D
- Maximovitch, D
- Vioque, J
- Navarrete Munoz, EM
- Aragones, N
- Martin, V
- Hernandez Ramirez, RU
- Bertuccio, P
- Ward, MH
- Malekzadeh, R
- Pourfarzi, F
- Mu, LN
- Lopez Cervantes, M
- Persiani, R
- Kurtz, RC
- Lagiou, A
- Lagiou, P
- Boffetta, P
- Boccia, S
- Negri, E
- Camargo, MC
- Curado, MP
- La Vecchia, C
Unidades de investigação
Abstract
The consumption of processed meat has been associated with noncardia gastric cancer, but evidence regarding a possible role of red meat is more limited. Our study aims to quantify the association between meat consumption, namely white, red and processed meat, and the risk of gastric cancer, through individual participant data meta-analysis of studies participating in the "Stomach cancer Pooling (StoP) Project". Data from 22 studies, including 11,443 cases and 28,029 controls, were used. Study-specific odds ratios (ORs) were pooled through a two-stage approach based on random-effects models. An exposure-response relationship was modeled, using one and two-order fractional polynomials, to evaluate the possible nonlinear association between meat intake and gastric cancer. An increased risk of gastric cancer was observed for the consumption of all types of meat (highest vs. lowest tertile), which was statistically significant for red (OR: 1.24; 95% CI: 1.00-1.53), processed (OR: 1.23; 95% CI: 1.06-1.43) and total meat (OR: 1.30; 95% CI: 1.09-1.55). Exposure-response analyses showed an increasing risk of gastric cancer with increasing consumption of both processed and red meat, with the highest OR being observed for an intake of 150 g/day of red meat (OR: 1.85; 95% CI: 1.56-2.20). This work provides robust evidence on the relation between the consumption of different types of meat and gastric cancer. Adherence to dietary recommendations to reduce meat consumption may contribute to a reduction in the burden of gastric cancer.
Dados da publicação
- ISSN/ISSNe:
- 0020-7136, 1097-0215
- Tipo:
- Article
- Páginas:
- 45-55
- DOI:
- 10.1002/ijc.32707
- Link para outro recurso:
- www.scopus.com
International Journal of Cancer Wiley-Liss Inc.
Citações Recebidas na Web of Science: 40
Citações Recebidas na Scopus: 50
Documentos
- Não há documentos
Filiações
Keywords
- diet; meat; nutrition; pooled analysis; stomach neoplasms
Financiamento
Proyectos asociados
RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2019
Citar a publicação
Ferro A,Rosato V,Rota M,Costa AR,Morais S,Pelucchi C,Johnson KC,Hu JF,Palli D,Ferraroni M,Zhang ZF,Bonzi R,Yu GP,Peleteiro B,Lopez L,Tsugane S,Hamada GS,Hidaka A,Zaridze D,Maximovitch D,Vioque J,Navarrete EM,Aragones N,Martin V,Hernandez RU,Bertuccio P,Ward MH,Malekzadeh R,Pourfarzi F,Mu LN,Lopez M,Persiani R,Kurtz RC,Lagiou A,Lagiou P,Boffetta P,Boccia S,Negri E,Camargo MC,Curado MP,La Vecchia C,Lunet N. Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project. Int. J. Cancer. 2020. 147. (1):p. 45-55. IF:7,396. (1).
