Portal de investigação
Hyperlipidaemia and cardioprotection: Animal models for translational studies
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Andreadou, I
- Schulz, R
- Badimon, L
- Adameová, A
- Kleinbongard, P
- Lecour, S
- Nikolaou, PE
- Vilahur, G
- Woudberg, N
- Heusch, G
- Ferdinandy, P
Unidades de investigação
Abstract
Hyperlipidaemia is a well-established risk factor for cardiovascular diseases and therefore, many animal model have been developed to mimic the human abnormal elevation of blood lipid levels. In parallel, extensive research for the alleviation of ischaemia/reperfusion injury has revealed that hyperlipidaemia is a major co-morbidity that attenuates the cardioprotective effect of conditioning strategies (preconditioning, postconditioning and remote conditioning) and that of pharmacological interventions by interfering with cardioprotective signalling pathways. In the present review article, we summarize the existing data on animal models of hypercholesterolaemia (total, low density and HDL abnormalities) and hypertriglyceridaemia used in ischaemia/reperfusion injury and protection from it. We also provide recommendations on preclinical animal models to be used for translations of the cardioprotective strategies into clinical practice.
Dados da publicação
- ISSN/ISSNe:
- 1476-5381, 0007-1188
- Tipo:
- Review
- Páginas:
- 5287-5311
- DOI:
- 10.1111/bph.14931
- Link para outro recurso:
- www.scopus.com
British Journal of Pharmacology Wiley-Blackwell
Citações Recebidas na Web of Science: 35
Citações Recebidas na Scopus: 45
Documentos
- Não há documentos
Filiações
Keywords
- HIGH-DENSITY-LIPOPROTEIN; ISCHEMIA-REPERFUSION INJURY; CORONARY-ARTERY-DISEASE; ESTER TRANSFER PROTEIN; INFARCT SIZE; METABOLIC SYNDROME; KNOCKOUT MICE; ISCHEMIA/REPERFUSION INJURY; SPHINGOSINE 1-PHOSPHATE; ATHEROSCLEROTIC LESIONS
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Citar a publicação
Andreadou I,Schulz R,Badimon L,Adameová A,Kleinbongard P,Lecour S,Nikolaou PE,Falcao I,Vilahur G,Woudberg N,Heusch G,Ferdinandy P. Hyperlipidaemia and cardioprotection: Animal models for translational studies. Br. J. Pharmacol. 2020. 177(23):p. 5287-5311. IF:8,739. (1).
