Portal de investigação
Reducing socio-economic inequalities in all-cause mortality: a counterfactual mediation approach
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Laine, JE
- Baltar, VT
- Stringhini, S
- Gandini, M
- Chadeau-Hyam, M
- Kivimaki, M
- Severi, G
- Perduca, V
- Hodge, AM
- Dugué, PA
- Giles, GG
- Milne, RL
- Sacerdote, C
- Krogh, V
- Panico, S
- Tumino, R
- Goldberg, M
- Zins, M
- Delpierre, C
- Alenius, H
- Vineis, P
Unidades de investigação
Abstract
Background: Socio-economic inequalities in mortality are well established, yet the contribution of intermediate risk factors that may underlie these relationships remains unclear. We evaluated the role of multiple modifiable intermediate risk factors underlying socio-economic-associated mortality and quantified the potential impact of reducing early all-cause mortality by hypothetically altering socio-economic risk factors. Methods: Data were from seven cohort studies participating in the LIFEPATH Consortium (total n=179090). Using both socio-economic position (SEP) (based on occupation) and education, we estimated the natural direct effect on all-cause mortality and the natural indirect effect via the joint mediating role of smoking, alcohol intake, dietary patterns, physical activity, body mass index, hypertension, diabetes and coronary artery disease. Hazard ratios (HRs) were estimated, using counterfactual natural effect models under different hypothetical actions of either lower or higher SEP or education. Results: Lower SEP and education were associated with an increase in all-cause mortality within an average follow-up time of 17.5years. Mortality was reduced via modelled hypothetical actions of increasing SEP or education. Through higher education, the HR was 0.85 [95% confidence interval (CI) 0.84, 0.86] for women and 0.71 (95% CI 0.70, 0.74) for men, compared with lower education. In addition, 34% and 38% of the effect was jointly mediated for women and men, respectively. The benefits from altering SEP were slightly more modest. Conclusions: These observational findings support policies to reduce mortality both through improving socio-economic circumstances and increasing education, and by altering intermediaries, such as lifestyle behaviours and morbidities.
Dados da publicação
- ISSN/ISSNe:
- 1464-3685, 0300-5771
- Tipo:
- Article
- Páginas:
- 497-510
- DOI:
- 10.1093/ije/dyz248
International Journal of Epidemiology Oxford University Press
Citações Recebidas na Web of Science: 26
Documentos
- Não há documentos
Filiações
Keywords
- Socio-economic inequalities; all-cause mortality; mediation; intervention; health behaviours; causal inference; multiple mediators
Campos de estudo
Financiamento
Proyectos asociados
Estudo dos factores de risco cardiovascular numa população adulta da Província do Bengo, Angola
Investigador Principal: José Henrique Dias Pinto de Barros
Estudo Clínico Académico . 2019
Citar a publicação
Laine JE,Baltar VT,Stringhini S,Gandini M,Chadeau M,Kivimaki M,Severi G,Perduca V,Hodge AM,Dugué PA,Giles GG,Milne RL,Barros H,Sacerdote C,Krogh V,Panico S,Tumino R,Goldberg M,Zins M,Delpierre C,Alenius H,Vineis P. Reducing socio-economic inequalities in all-cause mortality: a counterfactual mediation approach. Int. J. Epidemiol. 2020. 49. (2):p. 497-510. IF:7,196. (1).
