Portal de investigação
Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Ferro, A
- Costa, AR
- Morais, S
- Bertuccio, P
- Rota, M
- Pelucchi, C
- Hu, JF
- Johnson, KC
- Zhang, ZF
- Palli, D
- Ferraroni, M
- Yu, GP
- Bonzi, R
- López-Carrillo, L
- Tsugane, S
- Hamada, GS
- Hidaka, A
- Malekzadeh, R
- Zaridze, D
- Maximovich, D
- Vioque, J
- Navarrete-Muñoz, EM
- Alguacil, J
- Castaño-Vinyals, G
- Wolk, A
- Håkansson, N
- Hernández-Ramírez, RU
- Pakseresht, M
- Ward, MH
- Pourfarzi, F
- Mu, LN
- López-Cervantes, M
- Persiani, R
- Kurtz, RC
- Lagiou, A
- Lagiou, P
- Boffetta, P
- Boccia, S
- Negri, E
- Camargo, MC
- Curado, MP
- La Vecchia, C
Unidades de investigação
Abstract
A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.
Dados da publicação
- ISSN/ISSNe:
- 0020-7136, 1097-0215
- Tipo:
- Article
- Páginas:
- 3090-3101
- DOI:
- 10.1002/ijc.33134
- Link para outro recurso:
- www.scopus.com
International Journal of Cancer Wiley-Liss Inc.
Citações Recebidas na Web of Science: 22
Citações Recebidas na Scopus: 34
Documentos
- Não há documentos
Filiações
Keywords
- fruits; gastric cancer; nutrition; pooled analyses; vegetables
Financiamento
Proyectos asociados
RISK AND SURVIVAL OF GASTRIC CANCER RELATES SECOND PRIMARY TUMOURS: A COMPETING RISKS FRAMEWORK
Investigador Principal: Nuno Miguel de Sousa Lunet
Estudo Clínico Académico . 2019
Citar a publicação
Ferro A,Costa AR,Morais S,Bertuccio P,Rota M,Pelucchi C,Hu JF,Johnson KC,Zhang ZF,Palli D,Ferraroni M,Yu GP,Bonzi R,Peleteiro B,López L,Tsugane S,Hamada GS,Hidaka A,Malekzadeh R,Zaridze D,Maximovich D,Vioque J,Navarrete EM,Alguacil J,Castaño G,Wolk A,Håkansson N,Hernández RU,Pakseresht M,Ward MH,Pourfarzi F,Mu LN,López M,Persiani R,Kurtz RC,Lagiou A,Lagiou P,Boffetta P,Boccia S,Negri E,Camargo MC,Curado MP,La Vecchia C,Lunet N. Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project. Int. J. Cancer. 2020. 147. (11):p. 3090-3101. IF:7,396. (1).
