Portal de investigação
Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Lopes, J
- Borralho, P
- Coelho, R
- Cotter, J
- de Castro, FD
- de Sousa, HT
- Salgado, M
- Andrade, P
- Vieira, AI
- Figueiredo, P
- Caldeira, P
- Sousa, A
- Duarte, MA
- Avila, F
- Silva, J
- Moleiro, J
- Mendes, S
- Giestas, S
- Ministro, P
- Sousa, P
- Gonçalves, R
- Gonçalves, B
- Oliveira, A
- Chagas, C
- Cravo, M
- Afonso, J
- Portela, F
- Santiago, M
- Geboes, K
- Portuguese IBD Study Grp GEDII
Unidades de investigação
Abstract
Background and Aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and the ability of faecal calprotectin [FC] levels to discriminate between these statuses. Methods: This was an analysis of three prospective cohorts including 422 patients previously enrolled in other studies. Results: The two continuous scores [GS and RHI] were shown to be significantly correlated [correlation coefficient of 0.806, p < 0.001] and particularly close regarding their definition of histological response: 95% and 88% of all patients classified as having/not having [respectively] histological response according to RHI also did so according to GS. Moreover, median FC levels in patients with histological response were lower than those in patients without histological response [GS: 73.00 vs 525.00, p < 0.001; RHI: 73.50 vs 510.00, p < 0.001]; a similar trend was observed when FC levels of patients in histological remission were compared to those of patients with histological activity [GS: 76.00 vs 228.00, p < 0.001; RHI: 73.50 vs 467.00, p < 0.001]. FC levels allowed us to exclude the absence of histological remission [according to RHI] and absence of histological response [according to RHI and GS], with negative predictive values varying from 82% to 96%. However, optimization of the FC cut-off to exclude the absence of histological remission, as for the continuous GS, falls within values that resemble those of the healthy population. Conclusion: The continuous GS and RHI histological scores are strongly correlated in their definitions of histological response. An absence of histological remission could only be excluded at physiological levels of FC.
Dados da publicação
- ISSN/ISSNe:
- 1873-9946, 1876-4479
- Tipo:
- Article
- Páginas:
- 169-175
- Link para outro recurso:
- www.scopus.com
JOURNAL OF CROHNS & COLITIS Oxford University Press
Citações Recebidas na Web of Science: 22
Citações Recebidas na Scopus: 28
Documentos
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Filiações
Keywords
- endoscopic activity; histological activity; ulcerative colitis
Proyectos asociados
Contributo da endoscopia, biomarcadores e imagiologia na evolução clinica dos doentes com doença inflamatória intestinal
Investigador Principal: Fernando José Magro Dias
Estudo Clínico Académico . 2019
Citar a publicação
Magro F,Lopes J,Borralho P,Lopes S,Coelho R,Cotter J,de Castro FD,de Sousa HT,Salgado M,Andrade P,Vieira AI,Figueiredo P,Caldeira P,Sousa A,Duarte MA,Avila F,Silva J,Moleiro J,Mendes S,Giestas S,Ministro P,Sousa P,Gonçalves R,Gonçalves B,Oliveira A,Chagas C,Cravo M,Dias CC,Afonso J,Portela F,Santiago M,Geboes K,Carneiro F,Portuguese IBD Study GEDII GRP. Comparing the Continuous Geboes Score With the Robarts Histopathology Index: Definitions of Histological Remission and Response and their Relation to Faecal Calprotectin Levels. J. Crohn's Colitis. 2020. 14. (2):p. 169-175. IF:9,071. (1).
