Portal de investigação
Molecular Pathology of Non-familial Follicular Epithelial-Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification
Autores da FMUP
Participantes de fora da FMUP
- Povoa, AA
- Melo, M
- Vinagre, J
- Eloy, C
- Cameselle Teijeiro, JM
- Sobrinho Simoes, M
Unidades de investigação
Abstract
This review addresses the impact of molecular alterations on the diagnosis and prognosis of differentiated thyroid carcinoma (DTC), including papillary, follicular, and well-differentiated carcinoma NOS, as well as oncocytic neoplasms. The molecular characterization of DTC is based upon the well-established dichotomy of BRAF-like and RAS-like designations, together with a remaining third group, less homogeneous, composed of non-BRAF-/non-RAS-like tumors. The role of BRAF V600E mutation in risk stratification is discussed in the clinico-pathological context, namely, staging and invasive features of classic papillary thyroid carcinoma (PTC) and histopathological variants carrying an excellent prognosis (microPTC) or a guarded prognosis, including the aggressive variants tall cell and hobnail cell PTCs. In follicular patterned tumors, namely, follicular thyroid carcinoma (FTC), with or without oncocytic features, the most prevalent molecular alteration are RAS mutations that do not carry prognostic significance. The only genetic alteration that has been proven to play a role in risk stratification of PTC and FTC is TERT promoter (TERTp) mutation.
Dados da publicação
- ISSN/ISSNe:
- 1559-0097, 1046-3976
- Tipo:
- Review
- Páginas:
- 44-62
- Link para outro recurso:
- www.scopus.com
Endocrine Pathology Humana Press
Citações Recebidas na Web of Science: 20
Citações Recebidas na Scopus: 26
Documentos
- Não há documentos
Filiações
Keywords
- Thyroid cancer; BRAF; TERT  Prognosis; Outcome
Campos de estudo
Financiamento
Proyectos asociados
Mitochondrial complex II genetic characterization and enzymatic expression profile in tumours of the adrenal cortex and medulla
Investigador Principal: Valdemar de Jesus Conde Máximo
Estudo Clínico Académico (Mitochondrial) . 2020
Citar a publicação
Soares Dias Ferreira A,Povoa AA,Melo M,Vinagre J,Máximo V,Eloy C,Cameselle JM,Sobrinho M. Molecular Pathology of Non-familial Follicular Epithelial-Derived Thyroid Cancer in Adults: From <i>RAS/BRAF</i>-like Tumor Designations to Molecular Risk Stratification. Endocr. Pathol. 2021. 32(1):p. 44-62. IF:4,056. (2).
