Portal de investigação
Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Nogueira Rodrigues, J
- Leite, SC
- Pinto Costa, R
- Sousa, SC
- Luz, LL
- Sintra, MA
- Oliveira, R
- Monteiro, AC
- Pinheiro, GG
- Vitorino, M
- Silva, J.
- Simao, S
- Fernandes, VE
- Provaznik, J
- Benes, V
- Safronov, BV
- Magalhaes, A
- Vieira, J.
- Vieira, C.
- Tiscornia, G
- Araujo, IM
- Sousa, M.
Unidades de investigação
Abstract
Regeneration of adult mammalian central nervous system (CNS) axons is abortive, resulting in inability to recover function after CNS lesion, including spinal cord injury (SCI). Here, we show that the spiny mouse (Acomys) is an exception to other mammals, being capable of spontaneous and fast restoration of function after severe SCI, re-establishing hind limb coordination. Remarkably, Acomys assembles a scarless pro-regenerative tissue at the injury site, providing a unique structural continuity of the initial spinal cord geometry. The Acomys SCI site shows robust axon regeneration of multiple tracts, synapse formation, and electrophysiological signal propagation. Transcriptomic analysis of the spinal cord following transcriptome reconstruction revealed that Acomys rewires glycosylation biosynthetic pathways, culminating in a specific pro-regenerative proteoglycan signature at SCI site. Our work uncovers that a glycosylation switch is critical for axon regeneration after SCI and identifies beta 3gnt7, a crucial enzyme of keratan sulfate biosynthesis, as an enhancer of axon growth.
Dados da publicação
- ISSN/ISSNe:
- 1534-5807, 1878-1551
- Tipo:
- Article
- Páginas:
- 440-440
- Link para outro recurso:
- www.scopus.com
Developmental Cell Cell Press
Citações Recebidas na Web of Science: 18
Citações Recebidas na Scopus: 32
Documentos
- Não há documentos
Filiações
Keywords
- PLASTICITY; MOUSE
Financiamento
Proyectos asociados
Expression of Thomsen-Friedenreich Antigen in colorectal cancer and association with microsatellite instability
Investigador Principal: Celso Albuquerque Reis
Estudo Clínico Académico . 2021
Management of Neurogenic Detrusor Overactivity Caused by Spinal Cord Injury - The Case of Botulinum Toxin and Resiniferatoxin
Investigador Principal: Célia da Conceição Duarte Cruz
Estudo Clínico Académico . 2020
Citar a publicação
Nogueira J,Leite SC,Pinto R,Sousa SC,Luz LL,Sintra MA,Oliveira R,Monteiro AC,Pinheiro GG,Vitorino M,Silva J,Simao S,Fernandes VE,Provaznik J,Benes V,Cruz C,Safronov BV,Magalhaes A,Reis CA,Vieira J,Vieira C,Tiscornia G,Araujo IM,Sousa M. Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection. Dev. Cell. 2022. 57. (4):p. 440-440. IF:11,800. (1).
