Portal de investigação
KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Pereira, F
- Ferreira, A
- Sousa, MJ
- Oliveira, MJ
- Preto, A
Abstract
KRAS mutations are one of the most frequent oncogenic mutations of all human cancers, being more prevalent in pancreatic, colorectal, and lung cancers. Intensive efforts have been encouraged in order to understand the effect of KRAS mutations, not only on tumor cells but also on the dynamic network composed by the tumor microenvironment (TME). The relevance of the TME in cancer biology has been increasing due to its impact on the modulation of cancer cell activities, which can dictate the success of tumor progression. Here, we aimed to clarify the pro- and anti-inflammatory role of KRAS mutations over the TME, detailing the context and the signaling pathways involved. In this review, we expect to open new avenues for investigating the potential of KRAS mutations on inflammatory TME modulation, opening a different vision of therapeutic combined approaches to overcome KRAS-associated therapy inefficacy and resistance in cancer.
Dados da publicação
- ISSN/ISSNe:
- 2073-4409, 2073-4409
- Tipo:
- Review
- Páginas:
- -
Cells Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 14
Documentos
- Não há documentos
Filiações
Keywords
- KRAS mutations; tumor microenvironment; inflammation; pancreatic cancer; colorectal cancer; lung cancer; therapy
Campos de estudo
Financiamento
Proyectos asociados
Expression of Thomsen-Friedenreich Antigen in colorectal cancer and association with microsatellite instability
Investigador Principal: Celso Albuquerque Reis
Estudo Clínico Académico . 2021
Citar a publicação
Pereira F,Ferreira A,Reis CA,Sousa MJ,Oliveira MJ,Preto A. KRAS as a Modulator of the Inflammatory Tumor Microenvironment: Therapeutic Implications. Cells. 2022. 11(3):398. IF:6,000. (2).
