Portal de investigação
Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Merino-Ribas, A
- Araujo, R
- Pereira, L
- Campos, J
- Barreiros, L
- Segundo, M.
- Silva, N
- Costa, CFFA
- Trindade, F
- Alencastre, I
- Dumitrescu, IB
- Sampaio Maia, B.
Unidades de investigação
Abstract
Vascular calcification (VC) is a frequent condition in chronic kidney disease (CKD) and a well-established risk factor for the development of cardiovascular disease (CVD). Gut dysbiosis may contribute to CVD and inflammation in CKD patients. Nonetheless, the role of gut and blood microbiomes in CKD-associated VC remains unknown. Therefore, this pilot study aimed to explore the link between gut and blood microbiomes and VC in CKD patients on peritoneal dialysis (CKD-PD). Our results showed relative changes in specific taxa between CKD-PD patients with and without VC, namely Coprobacter, Coprococcus 3, Lactobacillus, and Eubacterium eligens group in the gut, and Cutibacterium, Pajaroellobacter, Devosia, Hyphomicrobium, and Pelomonas in the blood. An association between VC and all-cause mortality risk in CKD-PD patients was also observed, and patients with higher mortality risk corroborate the changes of Eubacterium eligens in the gut and Devosia genus in the blood. Although we did not find differences in uremic toxins, intestinal translocation markers, and inflammatory parameters among CKD-PD patients with and without VC, soluble CD14 (sCD14), a nonspecific marker of monocyte activation, positively correlated with VC severity. Therefore, gut Eubacterium eligens group, blood Devosia, and circulating sCD14 should be further explored as biomarkers for VC, CVD, and mortality risk in CKD.
Dados da publicação
- ISSN/ISSNe:
- 2218-273X, 2218-273X
- Tipo:
- Article
- Páginas:
- 867-
- DOI:
- 10.3390/biom12070867
- Link para outro recurso:
- www.scopus.com
Biomolecules Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 11
Citações Recebidas na Scopus: 21
Documentos
- Não há documentos
Filiações
Keywords
- chronic kidney disease; vascular calcification; gut microbiome; blood microbiome; mortality risk; sCD14
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Remodelling adversely impacts arrhythmic outcome following isolated aortic valve replacement surgery
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico (Remodelling) . 2020
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico . 2020
Citar a publicação
Merino A,Araujo R,Pereira L,Campos J,Barreiros L,Segundo M,Silva N,Costa C,Quelhas J,Trindade F,Falcao I,Alencastre I,Dumitrescu IB,Sampaio B. Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study. Biomolecules. 2022. 12. (7):p. 867-867. IF:5,500. (1).
