Portal de investigação
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Dados básicos
- Código:
- Estudo Clínico Académico
- Protocolo:
- Estudo Clínico Académico
- EUDRACT:
- NCT:
- Centro:
- Dotação:
- Ano de início:
- 2020
- Ano de conclusão:
Objectivos do projeto
Estudos Observacionais (STROBE statement); Natureza do Promotor: Academia – Tipo não comercial – Iniciativa do Investigador; Tipo de Centro: Unicêntrico – Cuidados Secundários
Documentos
- Não há documentos
Participantes
Unidades de investigação
Stakeholders - Promotores
Outputs do ensaio clínico
Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction.
Moreira-Costa, L; (...); Lourenço, AP
Article. 2024
Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function
Ciccarelli, M; (...); Tocchetti, CG
Review. 10.1093/cvr/cvad088. 2023
Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function.
Ciccarelli, M; (...); Tocchetti, CG
Review. 2023
Adverse remodeling in atrial fibrillation following isolated aortic valve replacement surgery.
Oliveira, JP; (...); Leite Moreira, A
Article. 2021
Alternatives to animal experimentation in cardiovascular research: human models of disease and biobanking
Falc?o Pires, I.
Article. 10.1093/eurheartj/ehad709. 2024
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
van der Velden, J; (...); Ciccarelli, M
Review. 10.1093/cvr/cvab370. 2022
Assessing Rodent Cardiac Function in vivo Using Hemodynamic Pressure-Volume Loops
Silva, D.; (...); Falc?o Pires, I.
Article. 10.3389/fphys.2021.751326. 2022
Assessing Rodent Cardiac Function in vivo Using Hemodynamic Pressure-Volume Loops.
Miranda Silva, D; (...); Falcao Pires, I
Article. 2022
Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis
Fragao-Marques, M; (...); Leite Moreira, A
Article. 10.1186/s12872-020-01754-0. 2020
Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease
Trindade, F; (...); Vitorino, R
Article. 10.1080/1354750X.2021.1904002. 2021
Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease.
Trindade, F; (...); Vitorino, R
Article. 2021
Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
Tocchetti, CG; (...); Thum, T
Article. 10.1093/cvr/cvaa222. 2020
Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
González, A; (...); Bayés-Genís, A
Review. 10.1002/ejhf.2493. 2022
Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
Aimo, A; (...); Bayes-Genis, A
Review. 10.1002/ejhf.2522. 2022
CARDIOMYOCYTE-DERIVED MICRORNA-30D REGULATES CARDIAC ANGIOGENESIS BY INHIBITING ENDOTHELIAL CELL MIGRATION
Videira, Raquel Figuinha; (...); Martins, Paula da Costa
Meeting Abstract. 2022
Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling
Ferreira, AF; (...); Falcao-Marques, I
Article. 10.1152/ajpheart.00200.2023. 2023
Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling (vol 325, pg H774, 2023)
Ferreira, Ana Filipa; (...); Falcao-Pires, Ines
Correction. 10.1152/ajpheart.00200.2023_COR. 2024
Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study
Perpetuo, L; (...); Vitorino, R.
Article. 10.3390/ijms232113579. 2022
Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study.
Perpetuo, L; (...); Vitorino, R
Article. 2022
Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis
Mancio, J; (...); Fontes Carvalho, R.
Article. 10.1093/ehjci/jeac092. 2022
Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis.
Mancio, J; (...); Fontes Carvalho, R
Article. 2022
Diet-Induced Microbiome's Impact on Heart Failure: A Double-Edged Sword
Rodrigues, A; (...); Falcao-Pires, I
Review. 10.3390/nu15051223. 2023
Diet-Induced Microbiome's Impact on Heart Failure: A Double-Edged Sword.
Rodrigues, A; (...); Falcao-Pires, I
Review. 2023
DISSECTING SEXUAL DIMORPHISM IN AORTIC VALVE STENOSIS BY PROTEOMICS
Grego, Ana; (...); Trindade, Fabio
Meeting Abstract. 2024
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction
Neves, J.; (...); Leite Moreira, A.
Article. 10.1089/thy.2022.0717. 2023
Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction.
Neves, JS; (...); Leite Moreira, A
Article. 2023
Electives in the medical curriculum - an opportunity to achieve students' satisfaction?
Ramalho, AR; (...); Falcao-Pires, I
Article. 10.1186/s12909-020-02269-0. 2020
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase G alpha oxidation.
Kolijn, D; (...); Hamdani, N
Article. 2021
Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Ga oxidation
Kolijn, D; (...); Hamdani, N
Article. 10.1093/cvr/cvaa123. 2021
Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation
Nogueira-Ferreira, R; (...); Moreira-Gonçalves, D
Article. 10.1016/j.bbadis.2023.166709. 2023
Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation.
Nogueira Ferreira, R; (...); Moreira Goncalves, D
Article. 2023
Fenofibrate and Heart Failure Outcomes in Patients With Type 2 Diabetes: Analysis From ACCORD
Ferreira, J.; (...); Leite Moreira, A.
Article. 10.2337/dc21-1977. 2022
Fenofibrate and Heart Failure Outcomes in Patients With Type 2 Diabetes: Analysis From ACCORD.
Ferreira, JP; (...); Leite-Moreira, A
Article. 2022
Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease
Diniz, MS; (...); Pereira, SP
Article. 10.1016/j.bbadis.2023.166834. 2023
Impact of cardiovascular risk factors in vascular remodelling of pregnant women
Ferreira, AF; (...); Falcao-Pires, I
Meeting Abstract. 2021
Impact of oral anticoagulation therapy on postoperative atrial fibrillation outcomes: a systematic review and meta-analysis
Fragao-Marques, M; (...); Leite Moreira, A.
Review. 10.1186/s12959-021-00342-2. 2021
Impact of oral anticoagulation therapy on postoperative atrial fibrillation outcomes: a systematic review and meta-analysis.
Fragao Marques, M; (...); Leite Moreira, A
Review. 2021
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action
Lecour, S; (...); Yellon, D
Article. 10.1007/s00395-021-00893-5. 2021
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action.
Lecour, S; (...); Yellon, D
Article. 2021
Increased Transglutaminase 2 Expression and Activity in Rodent Models of Obesity/Metabolic Syndrome and Aging
Penumatsa, KC; (...); Fanburg, BL
Article. 10.3389/fphys.2020.560019. 2020
Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis
Mancio, J; (...); Bettencourt Sousa, N.
Article. 10.1016/j.repc.2020.03.017. 2020
Ketones' impact on a dysmetabolic rat model of HFpEF
Goncalves, A; (...); Falcao-Pires, I
Meeting Abstract. 2023
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb
Diniz, MS; (...); Pereira, SP
Review. 10.3390/metabo13070845. 2023
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb.
Diniz, MS; (...); Pereira, SP
Review. 2023
Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg
Miranda-Silva, D; (...); Falcao-Pires, I
Review. 10.1007/s10741-020-10042-0. 2021
Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg.
Miranda Silva, D; (...); Falcao Pires, I
Review. 2021
MicroRNA-199b is involved in both LV and RV pathological remodeling through distinct molecular mechanisms
Silva, Joana; (...); Martins, Paula A. da Costa
Meeting Abstract. 10.1016/j.yjmcc.2022.08.099. 2022
Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases
Trindade, F; (...); Vitorino, R.
Review. 10.3390/ijms22115940. 2021
Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases.
Trindade, F; (...); Vitorino, R
Review. 2021
Mitochondrial Reversible Changes Determine Diastolic Function Adaptations During Myocardial (Reverse) Remodeling
Miranda-Silva, D; (...); Falcao-Pires, I
Article. 10.1161/CIRCHEARTFAILURE.119.006170. 2020
Myocardial phosphoproteomics and single cardiomyocyte force measurements endorse DYRK1A as a candidate therapeutic target for incomplete myocardial reverse remodelling after aortic valve replacement
Trindade, F.; (...); Falcao-Pires, I.
Meeting Abstract. 2023
Myocardial phosphoproteomics and single cardiomyocyte force measurements endorse DYRK1A as a candidate therapeutic target for incomplete reverse remodelling after aortic valve replacement
Trindade, FF; (...); Falcao-Pires, I
Meeting Abstract. 2023
Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease
Videira, RF, Martins, PAD, Falcao-Pires, I
Review. 10.3390/ijms21239285. 2020
Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
Bär, C; (...); Thum, T
Article. 10.1093/cvr/cvaa195. 2020
Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure
Trindade, F; (...); Vitorino, R
Article. 10.3390/proteomes10030030. 2022
Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure.
Trindade, F; (...); Vitorino, R
Article. 2022
Pericardial Fluid Annexin A1 Is a Marker of Atrial Fibrillation in Aortic Stenosis: A Proteomics Analysis
Fragao-Marques, M; (...); Trindade, F
Article. 10.3390/jpm12020264. 2022
Pericardial Fluid Annexin A1 Is a Marker of Atrial Fibrillation in Aortic Stenosis: A Proteomics Analysis.
Fragao Marques, M; (...); Trindade, F
Article. 2022
Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis
Fragao-Marques, M; (...); Falcao-Pires, I
Article. 10.3390/diagnostics11081422. 2021
Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis.
Fragao Marques, M; (...); Falcao Pires, I
Article. 2021
Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction
Silva, E; (...); Nascimento, D.
Meeting Abstract. 10.1093/cvr/cvac066.107. 2022
Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population
Fernandes, M; (...); Sampaio-Maia, B
Article. 10.3390/pathogens12010080. 2023
Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population.
Fernandes, M; (...); Sampaio-Maia, B
Article. 2023
Preoperative myocardial expression of E3 ubiquitin ligases in aortic stenosis patients undergoing valve replacement and their association to postoperative hypertrophy
Trindade, F; (...); Falcao-Pires, I
Article. 10.1371/journal.pone.0237000. 2020
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function
Ciccarelli, M; (...); Thum, T
Review. 10.1093/cvr/cvab009. 2021
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function.
Ciccarelli, M; (...); Thum, T
Review. 2021
Reverse remodelling of right ventricle induced by pregnancy
Machado Araujo, J.; (...); Falcao-Pires, I.
Meeting Abstract. 2023
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Goncalves Rodrigues, P; (...); Falcao-Pires, I
Article. 10.3791/60036. 2021
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents.
Goncalves Rodrigues, P; (...); Falcao Pires, I
Article. 2021
TARGETING PREMATURE AGING TO IMPROVE HFPEF
Silva, E. D.; (...); Nascimento, D. S.
Meeting Abstract. 2023
The adult heart requires baseline expression of the transcription factor Hand2 to withstand right ventricular pressure overload
Videira, RF; (...); Martins, PAD
Article. 10.1093/cvr/cvab299. 2022
The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive Stage
Bracchi, I; (...); Negrao, R
Article. 10.3390/biology13030163. 2024
The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive Stage.
Bracchi, I; (...); Negrao, R
Article. 2024
The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance & star;.
Azevedo, MJ; (...); Sampaio Maia, B
Article. 2023
The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance?
Azevedo, MJ; (...); Sampaio-Maia, B
Article. 10.1016/j.jdsr.2023.06.002. 2023
The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)-Molecular Signature Differ with the Extent of RR
Rodrigues, PG; (...); Falcao-Pires, I
Article. 10.3390/ijms21249687. 2020
The PERInatal MYocardial Remodeling (PERIMYR) cohort study protocol: A prospective study of cardiac remodeling and "recovery" in pregnancy as a model to understand the impact of comorbidities in cardiac remodeling and reverse remodeling
Ferreira, AF; (...); Falcao-Pires, I
Article. 10.1016/j.repc.2022.08.015. 2023
The senolyitc drug ABT-263 reverses HFpEF-associated inflammation, endothelial inflammation and fibrosis
Silva, EDS; (...); Nascimento, DSN
Meeting Abstract. 2021
Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction
Neves, J.; (...); Leite Moreira, A.
Review. 10.1177/2042018820958331. 2020
Towards standardization of echocardiography for evaluation of left ventricular function in adult rodents: a position paper of ESC working group on myocardial function
Zacchigna, Serena; (...); Sinagra, Gianfranco
Meeting Abstract. 2020
Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function
Zacchigna, S; (...); Thum, T
Review. 10.1093/cvr/cvaa110. 2021
Unraveling the Role of Epicardial Adipose Tissue in Coronary Artery Disease: Partners in Crime?
Conceiçao, G; (...); Falcao-Pires, I
Review. 10.3390/ijms21228866. 2020
Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction
Sebastiao, MJ; (...); Gomes-Alves, P
Article. 10.3390/biomedicines10112943. 2022
Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction.
Sebastiao, MJ; (...); Gomes-Alves, P
Article. 2022
Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study
Merino-Ribas, A; (...); Sampaio Maia, B.
Article. 10.3390/biom12070867. 2022
Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study.
Merino-Ribas, A; (...); Sampaio-Maia, B
Article. 2022
Vertical Transmission and Antifungal Susceptibility Profile of Yeast Isolates from the Oral Cavity, Gut, and Breastmilk of Mother-Child Pairs in Early Life
Azevedo, MJ; (...); Sampaio Maia, B.
Article. 10.3390/ijms24021449. 2023
Vertical Transmission and Antifungal Susceptibility Profile of Yeast Isolates from the Oral Cavity, Gut, and Breastmilk of Mother-Child Pairs in Early Life.
Azevedo, MJ; (...); Sampaio-Maia, B
Article. 2023
