1. Início
  2. Investigação Clínica
  3. The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome

The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome

Dados básicos

Código:
Estudo Clínico Académico
Protocolo:
Estudo Clínico Académico
EUDRACT:
NCT:
Centro:
Dotação:
Ano de início:
2020
Ano de conclusão:
Estudos observacionais Nacional Não Financiado Outros

Objectivos do projeto

Estudos Observacionais (STROBE statement); Natureza do Promotor: Academia – Tipo não comercial – Iniciativa do Investigador; Tipo de Centro: Unicêntrico – Cuidados Secundários

Documentos

  • Não há documentos

Participantes

Unidades de investigação

Stakeholders - Promotores

FMUP

Outputs do ensaio clínico

Acute and chronic effects of levosimendan in the ZSF1 obese rat model of heart failure with preserved ejection fraction.

Moreira-Costa, L; (...); Lourenço, AP

Article. 2024


Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function

Ciccarelli, M; (...); Tocchetti, CG

Review. 10.1093/cvr/cvad088. 2023


Acute heart failure: mechanisms and pre-clinical models-a Scientific Statement of the ESC Working Group on Myocardial Function.

Ciccarelli, M; (...); Tocchetti, CG

Review. 2023


Adverse remodeling in atrial fibrillation following isolated aortic valve replacement surgery.

Oliveira, JP; (...); Leite Moreira, A

Article. 2021


Alternatives to animal experimentation in cardiovascular research: human models of disease and biobanking

Falc?o Pires, I.

Article. 10.1093/eurheartj/ehad709. 2024


Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart

van der Velden, J; (...); Ciccarelli, M

Review. 10.1093/cvr/cvab370. 2022


Assessing Rodent Cardiac Function in vivo Using Hemodynamic Pressure-Volume Loops

Silva, D.; (...); Falc?o Pires, I.

Article. 10.3389/fphys.2021.751326. 2022


Assessing Rodent Cardiac Function in vivo Using Hemodynamic Pressure-Volume Loops.

Miranda Silva, D; (...); Falcao Pires, I

Article. 2022


Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis

Fragao-Marques, M; (...); Leite Moreira, A

Article. 10.1186/s12872-020-01754-0. 2020


Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease

Trindade, F; (...); Vitorino, R

Article. 10.1080/1354750X.2021.1904002. 2021


Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease.

Trindade, F; (...); Vitorino, R

Article. 2021


Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Tocchetti, CG; (...); Thum, T

Article. 10.1093/cvr/cvaa222. 2020


Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

González, A; (...); Bayés-Genís, A

Review. 10.1002/ejhf.2493. 2022


Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology

Aimo, A; (...); Bayes-Genis, A

Review. 10.1002/ejhf.2522. 2022


CARDIOMYOCYTE-DERIVED MICRORNA-30D REGULATES CARDIAC ANGIOGENESIS BY INHIBITING ENDOTHELIAL CELL MIGRATION

Videira, Raquel Figuinha; (...); Martins, Paula da Costa

Meeting Abstract. 2022


Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling

Ferreira, AF; (...); Falcao-Marques, I

Article. 10.1152/ajpheart.00200.2023. 2023


Cardiovascular risk factors during pregnancy impact the postpartum cardiac and vascular reverse remodeling (vol 325, pg H774, 2023)

Ferreira, Ana Filipa; (...); Falcao-Pires, Ines

Correction. 10.1152/ajpheart.00200.2023_COR. 2024


Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study

Perpetuo, L; (...); Vitorino, R.

Article. 10.3390/ijms232113579. 2022


Coronary Artery Disease and Aortic Valve Stenosis: A Urine Proteomics Study.

Perpetuo, L; (...); Vitorino, R

Article. 2022


Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis

Mancio, J; (...); Fontes Carvalho, R.

Article. 10.1093/ehjci/jeac092. 2022


Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis.

Mancio, J; (...); Fontes Carvalho, R

Article. 2022


Diet-Induced Microbiome's Impact on Heart Failure: A Double-Edged Sword

Rodrigues, A; (...); Falcao-Pires, I

Review. 10.3390/nu15051223. 2023


Diet-Induced Microbiome's Impact on Heart Failure: A Double-Edged Sword.

Rodrigues, A; (...); Falcao-Pires, I

Review. 2023


DISSECTING SEXUAL DIMORPHISM IN AORTIC VALVE STENOSIS BY PROTEOMICS

Grego, Ana; (...); Trindade, Fabio

Meeting Abstract. 2024


Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction

Neves, J.; (...); Leite Moreira, A.

Article. 10.1089/thy.2022.0717. 2023


Effects of Triiodothyronine Treatment in an Animal Model of Heart Failure with Preserved Ejection Fraction.

Neves, JS; (...); Leite Moreira, A

Article. 2023


Electives in the medical curriculum - an opportunity to achieve students' satisfaction?

Ramalho, AR; (...); Falcao-Pires, I

Article. 10.1186/s12909-020-02269-0. 2020


Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase G alpha oxidation.

Kolijn, D; (...); Hamdani, N

Article. 2021


Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Ga oxidation

Kolijn, D; (...); Hamdani, N

Article. 10.1093/cvr/cvaa123. 2021


Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation

Nogueira-Ferreira, R; (...); Moreira-Gonçalves, D

Article. 10.1016/j.bbadis.2023.166709. 2023


Exercise training impacts skeletal muscle remodelling induced by metabolic syndrome in ZSF1 rats through metabolism regulation.

Nogueira Ferreira, R; (...); Moreira Goncalves, D

Article. 2023


Fenofibrate and Heart Failure Outcomes in Patients With Type 2 Diabetes: Analysis From ACCORD

Ferreira, J.; (...); Leite Moreira, A.

Article. 10.2337/dc21-1977. 2022


Fenofibrate and Heart Failure Outcomes in Patients With Type 2 Diabetes: Analysis From ACCORD.

Ferreira, JP; (...); Leite-Moreira, A

Article. 2022


Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

Diniz, MS; (...); Pereira, SP

Article. 10.1016/j.bbadis.2023.166834. 2023


Impact of cardiovascular risk factors in vascular remodelling of pregnant women

Ferreira, AF; (...); Falcao-Pires, I

Meeting Abstract. 2021


Impact of oral anticoagulation therapy on postoperative atrial fibrillation outcomes: a systematic review and meta-analysis

Fragao-Marques, M; (...); Leite Moreira, A.

Review. 10.1186/s12959-021-00342-2. 2021


Impact of oral anticoagulation therapy on postoperative atrial fibrillation outcomes: a systematic review and meta-analysis.

Fragao Marques, M; (...); Leite Moreira, A

Review. 2021


IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action

Lecour, S; (...); Yellon, D

Article. 10.1007/s00395-021-00893-5. 2021


IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria: guidelines of the EU-CARDIOPROTECTION COST Action.

Lecour, S; (...); Yellon, D

Article. 2021


Increased Transglutaminase 2 Expression and Activity in Rodent Models of Obesity/Metabolic Syndrome and Aging

Penumatsa, KC; (...); Fanburg, BL

Article. 10.3389/fphys.2020.560019. 2020


Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis

Mancio, J; (...); Bettencourt Sousa, N.

Article. 10.1016/j.repc.2020.03.017. 2020


Ketones' impact on a dysmetabolic rat model of HFpEF

Goncalves, A; (...); Falcao-Pires, I

Meeting Abstract. 2023


Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Diniz, MS; (...); Pereira, SP

Review. 10.3390/metabo13070845. 2023


Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb.

Diniz, MS; (...); Pereira, SP

Review. 2023


Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg

Miranda-Silva, D; (...); Falcao-Pires, I

Review. 10.1007/s10741-020-10042-0. 2021


Mechanisms underlying the pathophysiology of heart failure with preserved ejection fraction: the tip of the iceberg.

Miranda Silva, D; (...); Falcao Pires, I

Review. 2021


MicroRNA-199b is involved in both LV and RV pathological remodeling through distinct molecular mechanisms

Silva, Joana; (...); Martins, Paula A. da Costa

Meeting Abstract. 10.1016/j.yjmcc.2022.08.099. 2022


Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases

Trindade, F; (...); Vitorino, R.

Review. 10.3390/ijms22115940. 2021


Mining the Biomarker Potential of the Urine Peptidome: From Amino Acids Properties to Proteases.

Trindade, F; (...); Vitorino, R

Review. 2021


Mitochondrial Reversible Changes Determine Diastolic Function Adaptations During Myocardial (Reverse) Remodeling

Miranda-Silva, D; (...); Falcao-Pires, I

Article. 10.1161/CIRCHEARTFAILURE.119.006170. 2020


Myocardial phosphoproteomics and single cardiomyocyte force measurements endorse DYRK1A as a candidate therapeutic target for incomplete myocardial reverse remodelling after aortic valve replacement

Trindade, F.; (...); Falcao-Pires, I.

Meeting Abstract. 2023


Myocardial phosphoproteomics and single cardiomyocyte force measurements endorse DYRK1A as a candidate therapeutic target for incomplete reverse remodelling after aortic valve replacement

Trindade, FF; (...); Falcao-Pires, I

Meeting Abstract. 2023


Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Videira, RF, Martins, PAD, Falcao-Pires, I

Review. 10.3390/ijms21239285. 2020


Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Bär, C; (...); Thum, T

Article. 10.1093/cvr/cvaa195. 2020


Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure

Trindade, F; (...); Vitorino, R

Article. 10.3390/proteomes10030030. 2022


Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure.

Trindade, F; (...); Vitorino, R

Article. 2022


Pericardial Fluid Annexin A1 Is a Marker of Atrial Fibrillation in Aortic Stenosis: A Proteomics Analysis

Fragao-Marques, M; (...); Trindade, F

Article. 10.3390/jpm12020264. 2022


Pericardial Fluid Annexin A1 Is a Marker of Atrial Fibrillation in Aortic Stenosis: A Proteomics Analysis.

Fragao Marques, M; (...); Trindade, F

Article. 2022


Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis

Fragao-Marques, M; (...); Falcao-Pires, I

Article. 10.3390/diagnostics11081422. 2021


Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis.

Fragao Marques, M; (...); Falcao Pires, I

Article. 2021


Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction

Silva, E; (...); Nascimento, D.

Meeting Abstract. 10.1093/cvr/cvac066.107. 2022


Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population

Fernandes, M; (...); Sampaio-Maia, B

Article. 10.3390/pathogens12010080. 2023


Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population.

Fernandes, M; (...); Sampaio-Maia, B

Article. 2023


Preoperative myocardial expression of E3 ubiquitin ligases in aortic stenosis patients undergoing valve replacement and their association to postoperative hypertrophy

Trindade, F; (...); Falcao-Pires, I

Article. 10.1371/journal.pone.0237000. 2020


Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function

Ciccarelli, M; (...); Thum, T

Review. 10.1093/cvr/cvab009. 2021


Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function.

Ciccarelli, M; (...); Thum, T

Review. 2021


Reverse remodelling of right ventricle induced by pregnancy

Machado Araujo, J.; (...); Falcao-Pires, I.

Meeting Abstract. 2023


Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Goncalves Rodrigues, P; (...); Falcao-Pires, I

Article. 10.3791/60036. 2021


Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents.

Goncalves Rodrigues, P; (...); Falcao Pires, I

Article. 2021


Targeting premature aging to improve HFpEF

Silva, EE; (...); Nascimento, D

Meeting Abstract. 2023


TARGETING PREMATURE AGING TO IMPROVE HFPEF

Silva, E. D.; (...); Nascimento, D. S.

Meeting Abstract. 2023


The adult heart requires baseline expression of the transcription factor Hand2 to withstand right ventricular pressure overload

Videira, RF; (...); Martins, PAD

Article. 10.1093/cvr/cvab299. 2022


The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive Stage

Bracchi, I; (...); Negrao, R

Article. 10.3390/biology13030163. 2024


The Cardiometabolic Impact of Rebaudioside A Exposure during the Reproductive Stage.

Bracchi, I; (...); Negrao, R

Article. 2024


The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance & star;.

Azevedo, MJ; (...); Sampaio Maia, B

Article. 2023


The contribution of maternal factors to the oral microbiota of the child: Influence from early life and clinical relevance?

Azevedo, MJ; (...); Sampaio-Maia, B

Article. 10.1016/j.jdsr.2023.06.002. 2023


The Degree of Cardiac Remodelling before Overload Relief Triggers Different Transcriptome and miRome Signatures during Reverse Remodelling (RR)-Molecular Signature Differ with the Extent of RR

Rodrigues, PG; (...); Falcao-Pires, I

Article. 10.3390/ijms21249687. 2020


The PERInatal MYocardial Remodeling (PERIMYR) cohort study protocol: A prospective study of cardiac remodeling and "recovery" in pregnancy as a model to understand the impact of comorbidities in cardiac remodeling and reverse remodeling

Ferreira, AF; (...); Falcao-Pires, I

Article. 10.1016/j.repc.2022.08.015. 2023


The senolyitc drug ABT-263 reverses HFpEF-associated inflammation, endothelial inflammation and fibrosis

Silva, EDS; (...); Nascimento, DSN

Meeting Abstract. 2021


Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction

Neves, J.; (...); Leite Moreira, A.

Review. 10.1177/2042018820958331. 2020


Towards standardization of echocardiography for evaluation of left ventricular function in adult rodents: a position paper of ESC working group on myocardial function

Zacchigna, Serena; (...); Sinagra, Gianfranco

Meeting Abstract. 2020


Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Zacchigna, S; (...); Thum, T

Review. 10.1093/cvr/cvaa110. 2021


Unraveling the Role of Epicardial Adipose Tissue in Coronary Artery Disease: Partners in Crime?

Conceiçao, G; (...); Falcao-Pires, I

Review. 10.3390/ijms21228866. 2020


Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction

Sebastiao, MJ; (...); Gomes-Alves, P

Article. 10.3390/biomedicines10112943. 2022


Unveiling Human Proteome Signatures of Heart Failure with Preserved Ejection Fraction.

Sebastiao, MJ; (...); Gomes-Alves, P

Article. 2022


Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study

Merino-Ribas, A; (...); Sampaio Maia, B.

Article. 10.3390/biom12070867. 2022


Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study.

Merino-Ribas, A; (...); Sampaio-Maia, B

Article. 2022


Vertical Transmission and Antifungal Susceptibility Profile of Yeast Isolates from the Oral Cavity, Gut, and Breastmilk of Mother-Child Pairs in Early Life

Azevedo, MJ; (...); Sampaio Maia, B.

Article. 10.3390/ijms24021449. 2023


Vertical Transmission and Antifungal Susceptibility Profile of Yeast Isolates from the Oral Cavity, Gut, and Breastmilk of Mother-Child Pairs in Early Life.

Azevedo, MJ; (...); Sampaio-Maia, B

Article. 2023


Potencial Role Of Micrornas As Biomakers And Therapeutic Targets During Left Ventricular Reverse Remodelling

Tese de doutoramento

Colaboradores: Inês Maria Falcão Sousa Pires Marques


Remodelling Adversely Impacts Arrhythmic Outcome Following Isolated Aortic Valve Replacement Surgery

Projeto de fim de curso

Colaboradores: Inês Maria Falcão Sousa Pires Marques


Remodelling Adversely Impacts Arrhythmic Outcome Following Isolated Aortic Valve Replacement Surgery

Dissertação de Mestrado

Colaboradores: Inês Maria Falcão Sousa Pires Marques


The Cross-Talk Between Adipose Tissue And Heart

Tese de doutoramento

Colaboradores: Inês Maria Falcão Sousa Pires Marques


Campos de estudo

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