Portal de investigação
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Ciccarelli, M
- Dawson, D
- Giacca, M
- Hamdani, N
- Heymans, S
- Hooghiemstra, A
- Leeuwis, A
- Hermkens, D
- Tocchetti, CG
- van der Velden, J
- Zacchigna, S
- Thum, T
Unidades de investigação
Abstract
Heart failure-either with reduced or preserved ejection fraction (HFrEF/HFpEF)-is a clinical syndrome of multi-factorial and gender-dependent aetiology, indicating the insufficiency of the heart to pump blood adequately to maintain blood flow to meet the body's needs. Typical symptoms commonly include shortness of breath, excessive fatigue with impaired exercise capacity, and peripheral oedema, thereby alluding to the fact that heart failure is a syndrome that affects multiple organ systems. Patients suffering from progressed heart failure have a very limited life expectancy, lower than that of numerous cancer types. In this position paper, we provide an overview regarding interactions between the heart and other organ systems, the clinical evidence, underlying mechanisms, potential available or yet-to-establish animal models to study such interactions and finally discuss potential new drug interventions to be developed in the future. Our working group suggests that more experimental research is required to understand the individual molecular mechanisms underlying heart failure and reinforces the urgency for tailored therapeutic interventions that target not only the heart but also other related affected organ systems to effectively treat heart failure as a clinical syndrome that affects and involves multiple organs.
Dados da publicação
- ISSN/ISSNe:
- 1755-3245, 0008-6363
- Tipo:
- Review
- Páginas:
- 2416-2433
- DOI:
- 10.1093/cvr/cvab009
- Link para outro recurso:
- www.scopus.com
Cardiovascular Research Oxford University Press
Citações Recebidas na Web of Science: 20
Citações Recebidas na Scopus: 28
Documentos
- Não há documentos
Filiações
Keywords
- Heart failure; Multi-organ clinical syndrome; Lung; Intestine; Kidney; Brain; Adipose tissue; Liver; Non-coding RNAs
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Remodelling adversely impacts arrhythmic outcome following isolated aortic valve replacement surgery
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico (Remodelling) . 2020
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico . 2020
Citar a publicação
Ciccarelli M,Dawson D,Falcao I,Giacca M,Hamdani N,Heymans S,Hooghiemstra A,Leeuwis A,Hermkens D,Tocchetti CG,van der Velden J,Zacchigna S,Thum T. Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function. Cardiovasc. Res. 2021. 117(12):p. 2416-2433. IF:13,081. (1).
