Portal de investigação
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- van der Velden, J
- Asselbergs, FW
- Bakkers, J
- Batkai, S
- Bertrand, L
- Bezzina, CR
- Bot, I
- Brundel, BJJM
- Carrier, L
- Chamuleau, S
- Dawson, MCD
- Davidson, SM
- Dendorfer, A
- Duncker, DJ
- Eschenhagen, T
- Fabritz, L
- Ferdinandy, P
- Giacca, M
- Girao, H
- Gollmann-Tepeköylü, C
- Gyongyosi, M
- Guzik, TJ
- Hamdani, N
- Heymans, S
- Hilfiker, A
- Hilfiker-Kleiner, D
- Hoekstra, AG
- Hulot, JS
- Kuster, DWD
- van Laake, LW
- Lecour, S
- Leiner, T
- Linke, WA
- Lumens, J
- Lutgens, E
- Madonna, R
- Maegdefessel, L
- Mayr, M
- van der Meer, P
- Passier, R
- Perbellini, F
- Perrino, C
- Pesce, M
- Priori, S
- Remme, CA
- Rosenhahn, B
- Schotten, U
- Schulz, R
- Sipido, KR
- Sluijter, JPG
- van Steenbeek, F
- Steffens, S
- Terracciano, CM
- Tocchetti, CG
- Vlasman, P
- Yeung, KK
- Zacchigna, S
- Zwaagman, D
- Thum, T
- Ciccarelli, M
Unidades de investigação
Abstract
Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover and test novel preventive and curative therapies, all of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task, in particular for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and comorbidities. This difficulty might lead some individuals to question the value of animal research, citing the translational 'valley of death', which largely reflects the fact that studies in rodents are difficult to translate to humans. This is also influenced by the fact that new, human-derived in vitro models can recapitulate aspects of disease processes. However, it would be a mistake to think that animal models do not represent a vital step in the translational pathway as they do provide important pathophysiological insights into disease mechanisms particularly on an organ and systemic level. While stem cell-derived human models have the potential to become key in testing toxicity and effectiveness of new drugs, we need to be realistic, and carefully validate all new human-like disease models. In this position paper, we highlight recent advances in trying to reduce the number of animals for cardiovascular research ranging from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and state-of-the-art animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. We aim to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction, and refinement (3R) as a guiding concept.
Dados da publicação
- ISSN/ISSNe:
- 1755-3245, 0008-6363
- Tipo:
- Review
- Páginas:
- 3016-3051
- DOI:
- 10.1093/cvr/cvab370
- Link para outro recurso:
- www.scopus.com
Cardiovascular Research Oxford University Press
Citações Recebidas na Web of Science: 26
Citações Recebidas na Scopus: 37
Documentos
- Não há documentos
Filiações
Keywords
- iPSC; Tissue engineering; Multiomics; Network medicine; Bioinformatics; Big data; Comorbidities; Cardiovascular disease
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Remodelling adversely impacts arrhythmic outcome following isolated aortic valve replacement surgery
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico (Remodelling) . 2020
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico . 2020
Citar a publicação
van der Velden J,Asselbergs FW,Bakkers J,Batkai S,Bertrand L,Bezzina CR,Bot I,Brundel BJJM,Carrier L,Chamuleau S,Dawson MCD,Davidson SM,Dendorfer A,Duncker DJ,Eschenhagen T,Fabritz L,Falcao I,Ferdinandy P,Giacca M,Girao H,Gollmann C,Gyongyosi M,Guzik TJ,Hamdani N,Heymans S,Hilfiker A,Hilfiker D,Hoekstra AG,Hulot JS,Kuster DWD,van LW,Lecour S,Leiner T,Linke WA,Lumens J,Lutgens E,Madonna R,Maegdefessel L,Mayr M,van der Meer P,Passier R,Perbellini F,Perrino C,Pesce M,Priori S,Remme CA,Rosenhahn B,Schotten U,Schulz R,Sipido KR,Sluijter JPG,van F,Steffens S,Terracciano CM,Tocchetti CG,Vlasman P,Yeung KK,Zacchigna S,Zwaagman D,Thum T,Ciccarelli M. Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart. Cardiovasc. Res. 2022. 118(15):p. 3016-3051. IF:10,800. (1).
