Portal de investigação
Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Bär, C
- Chatterjee, S
- Rodrigues, P
- Sluijter, JPG
- Boon, RA
- Nevado, RM
- Andrés, V
- Sansonetti, M
- de Windt, L
- Ciccarelli, M
- Hamdani, N
- Heymans, S
- Videira, RF
- Tocchetti, CG
- Giacca, M
- Zacchigna, S
- Engelhardt, S
- Dimmeler, S
- Madonna, R
- Thum, T
Unidades de investigação
Abstract
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.
Dados da publicação
- ISSN/ISSNe:
- 1755-3245, 0008-6363
- Tipo:
- Article
- Páginas:
- 1805-1819
- DOI:
- 10.1093/cvr/cvaa195
Cardiovascular Research Oxford University Press
Citações Recebidas na Web of Science: 35
Documentos
- Não há documentos
Filiações
Keywords
- Cardiovascular disease; Non-coding RNA; MicroRNA; Remodelling; Regeneration; Aging; Non-coding RNA therapy
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Remodelling adversely impacts arrhythmic outcome following isolated aortic valve replacement surgery
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico (Remodelling) . 2020
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico . 2020
Citar a publicação
Bär C,Chatterjee S,Pires IF,Rodrigues P,Sluijter JPG,Boon RA,Nevado RM,Andrés V,Sansonetti M,de Windt L,Ciccarelli M,Hamdani N,Heymans S,Videira RF,Tocchetti CG,Giacca M,Zacchigna S,Engelhardt S,Dimmeler S,Madonna R,Thum T. Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. Cardiovasc. Res. 2020. 116. (11):p. 1805-1819. IF:10,787. (1).
