Portal de investigação
Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- González, A
- Richards, AM
- de Boer, RA
- Thum, T
- Arfsten, H
- Hülsmann, M
- Díez, J
- Foo, RSY
- Chan, MY
- Aimo, A
- Anene-Nzelu, CG
- Abdelhamid, M
- Adamopoulos, S
- Anker, SD
- Belenkov, Y
- Gal, TB
- Cohen-Solal, A
- Böhm, M
- Chioncel, O
- Delgado, V
- Emdin, M
- Jankowska, EA
- Gustafsson, F
- Hill, L
- Jaarsma, T
- Januzzi, JL
- Jhund, PS
- Lopatin, Y
- Lund, LH
- Metra, M
- Milicic, D
- Mueller, C
- Mullens, W
- Núñez, J
- Piepoli, MF
- Rakisheva, A
- Ristic, AD
- Rossignol, P
- Savarese, G
- Tocchetti, CG
- Van Linthout, S
- Volterrani, M
- Seferovic, P
- Rosano, G
- Coats, AJS
- Bayés-Genís, A
Unidades de investigação
Abstract
Cardiac remodelling refers to changes in left ventricular structure and function over time, with a progressive deterioration that may lead to heart failure (HF) development (adverse remodelling) or vice versa a recovery (reverse remodelling) in response to HF treatment. Adverse remodelling predicts a worse outcome, whilst reverse remodelling predicts a better prognosis. The geometry, systolic and diastolic function and electric activity of the left ventricle are affected, as well as the left atrium and on the long term even right heart chambers. At a cellular and molecular level, remodelling involves all components of cardiac tissue: cardiomyocytes, fibroblasts, endothelial cells and leucocytes. The molecular, cellular and histological signatures of remodelling may differ according to the cause and severity of cardiac damage, and clearly to the global trend toward worsening or recovery. These processes cannot be routinely evaluated through endomyocardial biopsies, but may be reflected by circulating levels of several biomarkers. Different classes of biomarkers (e.g. proteins, non-coding RNAs, metabolites and/or epigenetic modifications) and several biomarkers of each class might inform on some aspects on HF development, progression and long-term outcomes, but most have failed to enter clinical practice. This may be due to the biological complexity of remodelling, so that no single biomarker could provide great insight on remodelling when assessed alone. Another possible reason is a still incomplete understanding of the role of biomarkers in the pathophysiology of cardiac remodelling. Such role will be investigated in the first part of this review paper on biomarkers of cardiac remodelling.
Dados da publicação
- ISSN/ISSNe:
- 1388-9842, 1879-0844
- Tipo:
- Review
- Páginas:
- 927-943
- DOI:
- 10.1002/ejhf.2493
- Link para outro recurso:
- www.scopus.com
European Journal of Heart Failure Wiley-Blackwell
Citações Recebidas na Web of Science: 23
Citações Recebidas na Scopus: 39
Documentos
- Não há documentos
Filiações
Keywords
- Biomarkers; Remodeling; Cells; Tissue
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Remodelling adversely impacts arrhythmic outcome following isolated aortic valve replacement surgery
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico (Remodelling) . 2020
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico . 2020
Citar a publicação
González A,Richards AM,de Boer RA,Thum T,Arfsten H,Hülsmann M,Falcao I,Díez J,Foo RSY,Chan MY,Aimo A,Anene CG,Abdelhamid M,Adamopoulos S,Anker SD,Belenkov Y,Gal TB,Cohen A,Böhm M,Chioncel O,Delgado V,Emdin M,Jankowska EA,Gustafsson F,Hill L,Jaarsma T,Januzzi JL,Jhund PS,Lopatin Y,Lund LH,Metra M,Milicic D,Moura B,Mueller C,Mullens W,Núñez J,Piepoli MF,Rakisheva A,Ristic AD,Rossignol P,Savarese G,Tocchetti CG,Van S,Volterrani M,Seferovic P,Rosano G,Coats A,Bayés A. Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2022. 24(6):p. 927-943. IF:18,200. (1).
