Portal de investigação
Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Diniz, MS
- Hiden, U
- Oliveira, PJ
- Sobrevia, L
- Pereira, SP
Unidades de investigação
Abstract
Gestational diabetes mellitus (GDM) and maternal obesity (MO) increase the risk of adverse fetal outcomes, and the incidence of cardiovascular disease later in life. Extensive research has been conducted to elucidate the underlying mechanisms by which GDM and MO program the offspring to disease. This review focuses on the role of fetoplacental endothelial dysfunction in programming the offspring for cardiovascular disease in GDM and MO pregnancies. We discuss how pre-existing maternal health conditions can lead to vascular dysfunction in the fetoplacental unit and the fetus. We also examine the role of fetoplacental endothelial dysfunction in impairing fetal cardiovascular system development and the involvement of nitric oxide and hydrogen sulfide in mediating fetoplacental vascular dysfunction. Furthermore, we suggest that the L-Arginine-Nitric Oxide and the AdenosineL-Arginine-Nitric Oxide (ALANO) signaling pathways are pertinent targets for research. Despite significant progress in this area, there are still knowledge gaps that need to be addressed in future research.
Dados da publicação
- ISSN/ISSNe:
- 0006-3002, 1879-260X
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Elsevier
Citações Recebidas na Web of Science: 4
Citações Recebidas na Scopus: 8
Documentos
- Não há documentos
Filiações
Keywords
- Gestational diabesity; Metabolic syndrome; Endothelial dysfunction; Cardiac function; Fetal development; Adenosine receptors; Nitric oxide
Financiamento
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Citar a publicação
Diniz MS,Hiden U,Falcao I,Oliveira PJ,Sobrevia L,Pereira SP. Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease. Biochim Biophys Acta. 2023. 1869. (8):166834. IF:6,200. (1).
