Portal de investigação
Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Zacchigna, S
- Paldino, A
- Daskalopoulos, EP
- Dal Ferro, M
- Vodret, S
- Lesizza, P
- Cannatà, A
- Miranda-Silva, D
- Pinamonti, B
- Sinagra, G
- Weinberger, F
- Eschenhagen, T
- Carrier, L
- Kehat, I
- Tocchetti, CG
- Russo, M
- Ghigo, A
- Cimino, J
- Hirsch, E
- Dawson, D
- Ciccarelli, M
- Oliveti, M
- Linke, WA
- Cuijpers, I
- Heymans, S
- Hamdani, N
- de Boer, M
- Duncker, DJ
- Kuster, D
- van der Velden, J
- Beauloye, C
- Bertrand, L
- Mayr, M
- Giacca, M
- Leuschner, F
- Backs, J
- Thum, T
- European Soc Cardiology
Unidades de investigação
Abstract
Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions. [GRAPHICS] .
Dados da publicação
- ISSN/ISSNe:
- 1755-3245, 0008-6363
- Tipo:
- Review
- Páginas:
- 43-59
- DOI:
- 10.1093/cvr/cvaa110
- Link para outro recurso:
- www.scopus.com
Cardiovascular Research Oxford University Press
Citações Recebidas na Web of Science: 65
Citações Recebidas na Scopus: 95
Documentos
- Não há documentos
Filiações
Keywords
- Echocardiography; Standardization; Animal models; Systolic function; Diastolic function
Financiamento
Proyectos asociados
Cardiac Remodelling and “Recovery” in Pregnancy as a Model to Understand the Mechanisms of CV Diseases.
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Observacional Académico (PERIMYR) . SP Cardiologia . 2019
Remodelling adversely impacts arrhythmic outcome following isolated aortic valve replacement surgery
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico (Remodelling) . 2020
The Heart under Pressure: Mechanisms underlying HEpEF Secondary to chronic pressure Overload or Metabolic Syndrome
Investigador Principal: Inês Maria Falcão Sousa Pires Marques
Estudo Clínico Académico . 2020
Citar a publicação
Zacchigna S,Paldino A,Falcao I,Daskalopoulos EP,Dal M,Vodret S,Lesizza P,Cannatà A,Miranda D,Lourenço AP,Pinamonti B,Sinagra G,Weinberger F,Eschenhagen T,Carrier L,Kehat I,Tocchetti CG,Russo M,Ghigo A,Cimino J,Hirsch E,Dawson D,Ciccarelli M,Oliveti M,Linke WA,Cuijpers I,Heymans S,Hamdani N,de Boer M,Duncker DJ,Kuster D,van der Velden J,Beauloye C,Bertrand L,Mayr M,Giacca M,Leuschner F,Backs J,Thum T,European C. Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function. Cardiovasc. Res. 2021. 117(1):p. 43-59. IF:13,081. (1).
