Interaction between the Renin-Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis

Data de publicação:

Autores da FMUP

  • Teresa Maria De Jesus Teixeira De Sousa

    Autor

  • Fernando José Magro Dias

    Autor

Participantes de fora da FMUP

  • Ferreira-Duarte, M
  • Rodrigues-Pinto, T
  • Faria, MA
  • Rocha, MS
  • Menezes-Pinto, D
  • Esteves-Monteiro, M
  • Dias-Pereira, P
  • Duarte-Araújo, M
  • Morato, M

Unidades de investigação

Abstract

Angiotensin II (Ang II) regulates colon contraction, acting not only directly on smooth muscle but also indirectly, interfering with myenteric neuromodulation mediated by the activation of AT(1) /AT(2) receptors. In this article, we aimed to explore which mediators and cells were involved in Ang II-mediated colonic contraction in the TNBS-induced rat model of colitis. The contractile responses to Ang II were evaluated in distinct regions of the colon of control animals or animals with colitis in the absence and presence of different antagonists/inhibitors. Endogenous levels of Ang II in the colon were assessed by ELISA and the number of AT(1)/AT(2) receptors by qPCR. Ang II caused AT(1) receptor-mediated colonic contraction that was markedly decreased along the colons of TNBS-induced rats, consistent with reduced AT(1) mRNA expression. However, the effect mediated by Ang II is much more intricate, involving (in addition to smooth muscle cells and nerve terminals) ICC and EGC, which communicate by releasing ACh and NO in a complex mechanism that changes colitis, unveiling new therapeutic targets.

Dados da publicação

ISSN/ISSNe:
1661-6596, 1661-6596

International Journal of Molecular Sciences  Multidisciplinary Digital Publishing Institute (MDPI)

Tipo:
Article
Páginas:
4836-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 11

Citações Recebidas na Scopus: 18

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Keywords

  • inflammatory bowel disease; IBD; TNBS-induced colitis; colonic dysmotility; angiotensin II; AT(1) and AT(2) receptors; nitric oxide; interstitial cells of Cajal; ICC; enteric glial cells; EGC

Financiamento

Proyectos asociados

Gut microbiome and IBD therapy: an interplay?

Investigador Principal: Fernando José Magro Dias

Estudo Observacional Académico (GutIBD) . 2021

Iron deficiency and inflammatory bowel disease. Correlation with inflammation and Vitamin D status.

Investigador Principal: Fernando José Magro Dias

Estudo Observacional Académico (IronIBD) . 2021

Looking 4WARD: The role of dipeptidyl peptidase 4 (DPP-4) in inflammatory bowel disease (IBD) as a novel biomarker for predicting disease activity and monitoring response to therapy in IBD patients.

Investigador Principal: Fernando José Magro Dias

Estudo Observacional Académico (4WARD) . 2021

Unresolved inflammation and endothelitis in severe COVID-19 patients: identification of risk stratification biomarkers and therapeutic targets. (severe COVID-19)

Investigador Principal: Teresa Maria de Jesus Teixeira de Sousa

Estudo Clínico Académico (Severe COVID-19) . FCT . 2020

Endocan: a novel biomarker for risk stratification, prognosis, and therapeutic monitoring in human cardiovascular and renal diseases

Investigador Principal: Teresa Maria de Jesus Teixeira de Sousa

Estudo Clínico Académico (Endocan) . 2020

Contributo da endoscopia, biomarcadores e imagiologia na evolução clinica dos doentes com doença inflamatória intestinal

Investigador Principal: Fernando José Magro Dias

Estudo Clínico Académico . 2019

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