The influence of the gastric microbiota in gastric cancer development
Autores da FMUP
Participantes de fora da FMUP
- Pereira-Marques, J
- Ferreira, RM
Unidades de investigação
Abstract
Colonization of the stomach by Helicobacter pylori is the trigger for a series of gastric mucosal changes that culminate in gastric cancer. Infection with this bacterium is considered the major risk factor for this malignancy. The introduction of high-throughput sequencing technologies coupled to advanced computational pipelines offered an improved understanding of the microbiome, and it is now currently accepted that, besides H. pylori, the stomach harbours a complex microbial community. While it is well established that H. pylori plays a central role in gastric carcinogenesis, the significance of the non H. pylori microbiota is yet to be clarified. This review will address the state of the art on the relationship between the gastric microbiota and gastric cancer development, and identify areas where additional research is needed before translating microbiome research into preventive and therapeutic strategies to reduce gastric cancer burden. (c) 2021 Elsevier Ltd. All rights reserved.
Dados da publicação
- ISSN/ISSNe:
- 1521-6918, 1532-1916
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY Bailliere Tindall Ltd
Citações Recebidas na Web of Science: 8
Citações Recebidas na Scopus: 14
Documentos
- Não há documentos
Filiações
Keywords
- Gastric microbiota; Helicobacter pylori; Gastric cancer; Gastric precancerous lesions
Financiamento
Proyectos asociados
Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions
Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo
Estudo Clínico Académico (Helicobacter) . 2019
Citar a publicação
Pereira J,Ferreira RM,Machado JC,Figueiredo C. The influence of the gastric microbiota in gastric cancer development. Best Pract. Res. Clin. Gastroenterol. 2021. 50-51. 101734. IF:2,695. (4).