The influence of the gastric microbiota in gastric cancer development

Data de publicação: Data Ahead of Print:

Autores da FMUP

  • José Carlos Lemos Machado

    Autor

  • Maria Do Céu Fontes Herdeiro Figueiredo

    Autor

Participantes de fora da FMUP

  • Pereira-Marques, J
  • Ferreira, RM

Unidades de investigação

Abstract

Colonization of the stomach by Helicobacter pylori is the trigger for a series of gastric mucosal changes that culminate in gastric cancer. Infection with this bacterium is considered the major risk factor for this malignancy. The introduction of high-throughput sequencing technologies coupled to advanced computational pipelines offered an improved understanding of the microbiome, and it is now currently accepted that, besides H. pylori, the stomach harbours a complex microbial community. While it is well established that H. pylori plays a central role in gastric carcinogenesis, the significance of the non H. pylori microbiota is yet to be clarified. This review will address the state of the art on the relationship between the gastric microbiota and gastric cancer development, and identify areas where additional research is needed before translating microbiome research into preventive and therapeutic strategies to reduce gastric cancer burden. (c) 2021 Elsevier Ltd. All rights reserved.

Dados da publicação

ISSN/ISSNe:
1521-6918, 1532-1916

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY  Bailliere Tindall Ltd

Tipo:
Article
Páginas:
-
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 8

Citações Recebidas na Scopus: 14

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Keywords

  • Gastric microbiota; Helicobacter pylori; Gastric cancer; Gastric precancerous lesions

Financiamento

Proyectos asociados

Unravelling Helicobacter pylori strategies to disrupt cell-cell junctions

Investigador Principal: Maria do Céu Fontes Herdeiro Figueiredo

Estudo Clínico Académico (Helicobacter) . 2019

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