Endocan: A novel biomarker for risk stratification, prognosis and therapeutic monitoring in human cardiovascular and renal diseases

Data de publicação:

Autores da FMUP

  • Marta Fernanda Reina Couto

    Autor

  • Teresa Maria De Jesus Teixeira De Sousa

    Autor

Participantes de fora da FMUP

  • Bessa, J
  • Albino Teixeira, A

Unidades de investigação

Abstract

The vascular endothelium is localized at the interface between the blood and surrounding tissues, playing a pivotal role in the maintenance of tissue-fluid homeostasis and in the regulation of host defense, inflammation, vascular tone and remodeling, angiogenesis and haemostasis. The dysfunctional endothelium was shown to be implicated in the pathophysiology of several endothelial-dependent disorders, such as arterial hypertension, coronary artery disease, heart failure and chronic kidney disease, in which it is an early predictor of cardiovascular events. Endocan is a soluble dermatan sulphate proteoglycan mainly secreted by the activated endothelium. It is upregulated by several proinflammatory cytokines and proangiogenic factors and may itself contribute to the inflammatory status. In addition of being a surrogate marker of inflammation and endothelial dysfunction, it seems to be involved in the regulation of several proliferative and neovascularization processes. Therefore, its utility as a biomarker in a wide spectrum of diseases has been increasingly explored. Here, we review the current evidence concerning the role of endocan in several human cardiovascular and renal diseases, where it seems to be a promising biomarker for risk stratification, prognosis and therapeutic monitoring.

Dados da publicação

ISSN/ISSNe:
0009-8981, 1873-3492

Clinica Chimica Acta  Elsevier

Tipo:
Article
Páginas:
310-335
Link para outro recurso:
www.scopus.com

Citações Recebidas na Web of Science: 22

Citações Recebidas na Scopus: 26

Documentos

  • Não há documentos

Métricas

Filiações mostrar / ocultar

Keywords

  • Endocan; Inflammation; Endothelial dysfunction; Cardiovascular diseases; Biomarker; Risk stratification

Financiamento

Proyectos asociados

Unresolved inflammation and endothelitis in severe COVID-19 patients: identification of risk stratification biomarkers and therapeutic targets. (severe COVID-19)

Investigador Principal: Teresa Maria de Jesus Teixeira de Sousa

Estudo Clínico Académico (Severe COVID-19) . FCT . 2020

Endocan: a novel biomarker for risk stratification, prognosis, and therapeutic monitoring in human cardiovascular and renal diseases

Investigador Principal: Teresa Maria de Jesus Teixeira de Sousa

Estudo Clínico Académico (Endocan) . 2020

Citar a publicação

Partilhar a publicação