Unhealthy Diets Induce Distinct and Regional Effects on Intestinal Inflammatory Signalling Pathways and Long-Lasting Metabolic Dysfunction in Rats

Autores da FMUP
Participantes de fora da FMUP
- Nogueira, S
- Barbosa, J
- Faria, J
- Fonseca, BM
- Leal, S
Unidades de investigação
Abstract
The intestinal epithelium is a principal site for environmental agents' detection. Several inflammation- and stress-related signalling pathways have been identified as key players in these processes. However, it is still unclear how the chronic intake of inadequate nutrients triggers inflammatory signalling pathways in different intestinal regions. We aimed to evaluate the impact of unhealthy dietary patterns, starting at a younger age, and the association with metabolic dysfunction, intestinal inflammatory response, and obesity in adulthood. A rat model was used to evaluate the effects of the consumption of sugary beverages (HSD) and a Western diet (WD), composed of ultra-processed foods. Both diets showed a positive correlation with adiposity index, but a positive correlation was found between the HSD diet and the levels of blood glucose and triglycerides, whereas the WD diet correlated positively with triglyceride levels. Moreover, a distinct inflammatory response was associated with either the WD or HSD diets. The WD induced an increase in TLR2, TLR4, and nuclear factor-kappa B (NF-kappa B) intestinal gene expression, with higher levels in the colon and overexpression of the inducible nitric oxide synthase. In turn, the HSD diet induced activation of the TLR2-mediated NF-kappa B signalling pathway in the small intestine. Altogether, these findings support the concept that early intake of unhealthy foods and nutrients are a main exogenous signal for disturbances of intestinal immune mechanisms and in a region-specific manner, ultimately leading to obesity-related disorders in later life.
Dados da publicação
- ISSN/ISSNe:
- 1661-6596, 1661-6596
- Tipo:
- Article
- Páginas:
- -
- Link para outro recurso:
- www.scopus.com
International Journal of Molecular Sciences Multidisciplinary Digital Publishing Institute (MDPI)
Documentos
- Não há documentos
Filiações
Keywords
- western diet; high-sugar diet; toll-like receptors; iNOS; intestinal inflammation; long-lasting metabolic effects
Financiamento
Proyectos asociados
Effects of Xanthohumol on Metabolic Syndrome Progression (XAN4Health) - NCT03561116
Investigador Principal: Raquel Ângela Silva Soares Lino
Ensaio Clínico Académico (XAN4Health) . TA XAN . 2019
Effects Of Chronic Tamoxifen Treatment In The Hypothalamic Circuitry That Regulates Female Sexual Behaviour
Investigador Principal: Susana Isabel Ferreira da Silva de Sá
Estudo Clínico Académico . 2021
SARS-CoV-2 e Angiogénese: uma ligação por explicar
Investigador Principal: Raquel Ângela Silva Soares Lino
Estudo Clínico Académico . 2021
The use of targeted angiogenic therapies for ischemic diabetic foot ulcer repair.
Investigador Principal: Raquel Ângela Silva Soares Lino
Estudo Clínico Académico . 2022
Citar a publicação
Nogueira S,Barbosa J,Faria J,S? S,Cardoso A,Soares R,Fonseca BM,Leal S. Unhealthy Diets Induce Distinct and Regional Effects on Intestinal Inflammatory Signalling Pathways and Long-Lasting Metabolic Dysfunction in Rats. Int. J. Mol. Sci. 2022. 23. (18):10984. IF:5,600. (1).