Portal de investigação
Effect of Raw and Roasted Phoenix dactylifera L. Seed Polyphenols Extracts on Suppression of Angiogenesis in Endothelial Cells
Autores da FMUP
Participantes de fora da FMUP
- Moeenfard, M
- Pena, MJ
- Barata, P
- Costa, R
Unidades de investigação
Abstract
Date seed is a by-product of Phoenix dactylifera L. fruit which is well recognized for its polyphenols content and numerous health-beneficial effects. Due to the increasing interest in natural phytochemicals with antioxidant activities, the present study aimed to extract polyphenols from both raw and roasted date seeds and investigate the anti-angiogenic effect of these two extracts (raw and roasted date seed polyphenols extracts (DSPE) at 25 and 50 mu g/mL) using human microvascular endothelial cells (HMVEC). Our results showed that both raw and roasted DSPE suppressed some angiogenesis features in a dose-dependent manner including cell proliferation, migration, and capillary-like structure formation, of which raw DSPE was more potent inhibitor than roasted DSPE. Reduction in reactive oxygen species, as well as enhancement of superoxide dismutase activity occurred using both raw and roasted date seed polyphenols extracts. However, no changes were observed in advanced oxidation protein products versus control. Taken together, our data indicated that raw and roasted DSPE possess antioxidant activity, which suggested their potential use as a source of polyphenols with anti-angiogenic properties. Nevertheless, further studies are required to explore the underlying mechanisms responsible for their anti-angiogenic activities.
Dados da publicação
- ISSN/ISSNe:
- 1573-9104, 0921-9668
- Tipo:
- Article
- Páginas:
- 560-567
- Link para outro recurso:
- www.scopus.com
Plant Foods for Human Nutrition Springer Netherlands
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 2
Documentos
- Não há documentos
Filiações
Keywords
- Date seed; Polyphenols; Angiogenesis; Antioxidant; Endothelial cells
Financiamento
Proyectos asociados
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Citar a publicação
Moeenfard M,Pena MJ,Barata P,Soares R,Costa R. Effect of Raw and Roasted <i>Phoenix dactylifera </i>L<i>.</i> Seed Polyphenols Extracts on Suppression of Angiogenesis in Endothelial Cells. Plant Foods Hum. Nutr. 2022. 77. (4):p. 560-567. IF:4,000. (1).
