Portal de investigação
Biocompatibility of the Biopolymer Cyanoflan for Applications in Skin Wound Healing
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Costa, R
- Costa, L
- Meireles, C
- Tamagnini, P
- Mota, R
Unidades de investigação
Abstract
There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by a marine unicellular cyanobacterium, was evaluated as a potential biomaterial for wound healing. Cyanoflan effects on cell viability, apoptosis, and migration were assessed in vitro, while the effect on tissue regeneration and biosafety was evaluated in healthy Wistar rats. The cell viability and apoptosis of fibroblasts and endothelial cells was not influenced by the treatment with different concentrations of Cyanoflan, as observed by flow cytometry. Moreover, the presence of Cyanoflan did not affect cell motility and migratory capacity, nor did it induce reactive oxygen species production, even revealing an antioxidant behavior regarding the endothelial cells. Furthermore, the skin wound healing in vivo assay demonstrated that Cyanoflan perfectly adapted to the wound bed without inducing systemic or local oxidative or inflammatory reaction. Altogether, these results suggest that Cyanoflan is a promising biopolymer for the development of innovative applications to overcome the many challenges that still exist in skin wound healing.
Dados da publicação
- ISSN/ISSNe:
- 1660-3397, 1660-3397
- Tipo:
- Article
- Páginas:
- 147-
- DOI:
- 10.3390/md19030147
- Link para outro recurso:
- www.scopus.com
Marine Drugs Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 9
Citações Recebidas na Scopus: 15
Documentos
- Não há documentos
Filiações
Keywords
- antioxidant; cyanobacteria; Cyanoflan; wound healing; wound dressings; skin regeneration
Financiamento
Proyectos asociados
Effects of Xanthohumol on Metabolic Syndrome Progression (XAN4Health) - NCT03561116
Investigador Principal: Raquel Ângela Silva Soares Lino
Ensaio Clínico Académico (XAN4Health) . TA XAN . 2019
Citar a publicação
Costa R,Costa L,Rodrigues I,Meireles C,Soares R,Tamagnini P,Mota R. Biocompatibility of the Biopolymer Cyanoflan for Applications in Skin Wound Healing. Mar. Drugs. 2021. 19. (3):p. 147-147. IF:6,085. (1).
