Portal de investigação
Expression of Thomsen-Friedenreich Antigen in Colorectal Cancer and Association with Microsatellite Instability
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Leao, B
- Wen, X
- Duarte, HO
- Gon?alves, G
- Pontes, P
- Castelli, C
- Diniz, F
- Mereiter, S
- Gomes, J
Unidades de investigação
Abstract
Microsatellite instability (MSI) is a molecular phenotype due to a deficient DNA mismatch repair (dMMR). In colorectal cancer (CRC), dMMR/MSI is associated with several clinical and histopathological features, influences prognosis, and is a predictive factor of response to therapy. In daily practice, dMMR/MSI profiles are identified by immunohistochemistry and/or multiplex PCR. The Thomsen-Friedenreich (TF) antigen was previously found to be a potential single marker to identify MSI-high gastric cancers. Therefore, in this study, we aimed to disclose a possible association between TF expression and MSI status in CRC. Furthermore, we evaluated the relationship between TF expression and other clinicopathological features, including patient survival. We evaluated the expression of the TF antigen in a cohort of 25 MSI-high and 71 microsatellite stable (MSS) CRCs. No association was observed between the expression of the TF antigen and MSI-high status in CRC. The survival analysis revealed that patients with MSI-high CRC showed improved survival when the TF antigen was expressed. This finding holds promise as it indicates the potential use of the TF antigen as a biomarker of better prognosis in MSI-high CRCs that should be validated in an independent and larger CRC cohort.
Dados da publicação
- ISSN/ISSNe:
- 1661-6596, 1661-6596
- Tipo:
- Article
- Páginas:
- 1-13
- DOI:
- 10.3390/ijms22031340
- Link para outro recurso:
- www.scopus.com
International Journal of Molecular Sciences Multidisciplinary Digital Publishing Institute (MDPI)
Citações Recebidas na Web of Science: 1
Citações Recebidas na Scopus: 4
Documentos
- Não há documentos
Filiações
Keywords
- glycosylation; colorectal cancer; microsatellite instability; Thomsen– Friedenreich antigen; O-glycan
Financiamento
Proyectos asociados
Gastric Cancer Morphological, Immunophenotypic and molecular heterogeneity
Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2020
Citar a publicação
Leao B,Wen X,Duarte HO,Gullo I,Gon?alves G,Pontes P,Castelli C,Diniz F,Mereiter S,Gomes J,Carneiro F,Reis CA. Expression of Thomsen-Friedenreich Antigen in Colorectal Cancer and Association with Microsatellite Instability. Int. J. Mol. Sci. 2021. 22. (3):p. 1-13. IF:6,208. (1).
