Portal de investigação
Diagnosis of digestive system tumours
Data de publicação:
Data Ahead of Print:
Autores da FMUP
Participantes de fora da FMUP
- Washington, MK
- Goldberg, RM
- Chang, GJ
- Limburg, P
- Lam, AK
- Salto-Tellez, M
- Arends, MJ
- Nagtegaal, ID
- Klimstra, DS
- Rugge, M
- Schirmacher, P
- Lazar, AJ
- Odze, RD
- Fukayama, M
- Cree, IA
- WHO Classification Tumours Ed
Unidades de investigação
Abstract
The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as the WHO Blue Books. The first volume to be produced is on the classification of Digestive System tumours, replacing the successful 2010 version. It has been rewritten and updated accordingly. This article summarises the major diagnostic innovations that have occurred over the last decade and that have now been incorporated in the classification. As an example, it incorporates the recently proposed classification of neuroendocrine tumours, based on the recognition that neuroendocrine tumours and carcinomas differ substantially in the genetic abnormalities that drive their growth, findings relevant to treatment selection and outcome prediction. Several themes have emerged during the production process. One is the importance of the progression from hyperplasia to dysplasia to carcinoma in the evolution of the malignant process. Advances in imaging techniques and endoscopy have resulted in enhanced access to precancerous lesions in the gastrointestinal and biliary tract, necessitating both changes in classification schema and clinical practice. Diagnosis of tumours is no longer the sole purview of pathologists, and some patients now receive treatment before tissue is obtained, based on clinical, radiological and liquid biopsy results. This makes the classification relevant to many disciplines involved in the care of patients with tumours of the digestive system.
Dados da publicação
- ISSN/ISSNe:
- 0020-7136, 1097-0215
- Tipo:
- Review
- Páginas:
- 1040-1050
- DOI:
- 10.1002/ijc.33210
- Link para outro recurso:
- www.scopus.com
International Journal of Cancer Wiley-Liss Inc.
Citações Recebidas na Web of Science: 30
Citações Recebidas na Scopus: 44
Documentos
- Não há documentos
Filiações
Keywords
- classification; diagnosis; diagnosis; digestive system; neoplasms; neuroendocrine; tumour
Proyectos asociados
Gastric Cancer Morphological, Immunophenotypic and molecular heterogeneity
Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2020
Citar a publicação
Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification Tumours ED. Diagnosis of digestive system tumours. Int. J. Cancer. 2021. 148(5):p. 1040-1050. IF:7,316. (1).
