Portal de investigação
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes
Data de publicação:
Autores da FMUP
Participantes de fora da FMUP
- Grillo, F
- Mastracci, L
- Vanoli, A
- Saragoni, L
- Limarzi, F
- Ferro, J
- Parente, P
- Fassan, M
Unidades de investigação
Abstract
Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently diagnosed malignancy and the third leading cause of cancer related death. Gastric carcinogenesis is a multistep and multifactorial process and is the result of the complex interplay between genetic susceptibility and environmental factors. The identification of predisposing conditions and of precancerous lesions is the basis for screening programs and early stage treatment. Furthermore, although most gastric cancers are sporadic, familial clustering is observed in up to 10% of patients. Among them, hereditary cases, related to known cancer susceptibility syndromes and/or genetic causes are thought to account for 1-3% of all gastric cancers. The pathology report of gastric resections specimens therefore requires a standardized approach as well as in depth knowledge of prognostic and treatment associated factors.
Dados da publicação
- ISSN/ISSNe:
- 0031-2983, 1591-951X
- Tipo:
- Review
- Páginas:
- 166-185
- Link para outro recurso:
- www.scopus.com
Pathologica Pacini Editore s.r.l.
Citações Recebidas na Web of Science: 40
Citações Recebidas na Scopus: 75
Documentos
- Não há documentos
Filiações
Keywords
- gastric cancer; gastric dysplasia; gastric adenocarcinoma; hereditary gastric cancer syndromes; hereditary diffuse gastric cancer (HDGC)
Proyectos asociados
Gastric Cancer Morphological, Immunophenotypic and molecular heterogeneity
Investigador Principal: Maria de Fátima Machado Henriques Carneiro
Estudo Clínico Académico . 2020
Citar a publicação
Gullo I,Grillo F,Mastracci L,Vanoli A,Carneiro F,Saragoni L,Limarzi F,Ferro J,Parente P,Fassan M. Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes. Pathologica. 2020. 112(3):p. 166-185.
