Portal de investigação
Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives
Autores da FMUP
Participantes de fora da FMUP
- Silva, L
- Coelho, P
- Teixeira, D
- Monteiro, A
- Pinto, G
- Prudêncio, C
- Vieira, M
Unidades de investigação
Abstract
Background: Quinoxaline-1,4-dioxide (QNX) derivatives are synthetic heterocyclic compounds with multiple biological and pharmacological effects. Objective: In this study, we investigated the oxidative status of quinoxaline-1,4-dioxides derivatives in modulating melanoma and glioma cell lines, based on previous results from the research group and their capability to promote cell damage by the production of Reactive Oxygen Species (ROS). Methods: Using in vitro cell cultures, the influence of 2-amino-3-cyanoquinoxaline-1,4-dioxide (2A3CQNX), 3-methyl-2-quinoxalinecarboxamide-1,4-dioxide (3M2QNXC) and 2-hydroxyphenazine-1,4-dioxide (2HF) was evaluated in metabolic activity, catalase activity, glutathione and 3-nitrotyrosine (3-NT) quantitation by HPLC in malignant melanocytes (B16-F10, MeWo) and brain tumor cells (GL-261 and BC3H1) submitted to radiotherapy treatments (total dose of 6 Gy). Results: 2HF increased the levels of 3-NT in non-irradiated MeWo and glioma cell lines and decreased cell viability in these cell lines with and without irradiation. Conclusion: Quinoxaline-1,4-dioxides derivatives modulate the oxidative status in malignant melanocytes and brain tumor cell lines and exhibited a potential radiosensitizer in vitro action on the tested radioresistant cell lines.
Dados da publicação
- ISSN/ISSNe:
- 1871-5206, 1875-5992
- Tipo:
- Article
- Páginas:
- 111-120
- Link para outro recurso:
- www.scopus.com
Anti-Cancer Agents in Medicinal Chemistry Bentham Science Publishers B.V.
Citações Recebidas na Web of Science: 3
Citações Recebidas na Scopus: 3
Documentos
- Não há documentos
Filiações
Keywords
- Quinoxaline-1,4-dioxides derivatives; oxidative stress; radiation resistance; melanoma; glioma; radiosensitizing
Financiamento
Proyectos asociados
Effects of Xanthohumol on Metabolic Syndrome Progression (XAN4Health) - NCT03561116
Investigador Principal: Raquel Ângela Silva Soares Lino
Ensaio Clínico Académico (XAN4Health) . TA XAN . 2019
Citar a publicação
Silva L,Coelho P,Teixeira D,Monteiro A,Pinto G,Soares R,Prudêncio C,Vieira M. Oxidative Stress Modulation and Radiosensitizing Effect of Quinoxaline-1,4-Dioxides Derivatives. Anti-Cancer Agents Med. Chem. 2020. 20. (1):p. 111-120. IF:2,505. (3).
